ID A0A0J7L1J1_LASNI Unreviewed; 878 AA.
AC A0A0J7L1J1;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Xaa-Pro dipeptidase {ECO:0000256|ARBA:ARBA00044141};
DE EC=3.4.13.9 {ECO:0000256|ARBA:ARBA00044051};
DE AltName: Full=Imidodipeptidase {ECO:0000256|ARBA:ARBA00044351};
DE AltName: Full=Peptidase D {ECO:0000256|ARBA:ARBA00044252};
DE AltName: Full=Proline dipeptidase {ECO:0000256|ARBA:ARBA00044284};
DE Flags: Fragment;
GN ORFNames=RF55_3246 {ECO:0000313|EMBL:KMQ96463.1};
OS Lasius niger (Black garden ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Lasius; Lasius.
OX NCBI_TaxID=67767 {ECO:0000313|EMBL:KMQ96463.1, ECO:0000313|Proteomes:UP000036403};
RN [1] {ECO:0000313|EMBL:KMQ96463.1, ECO:0000313|Proteomes:UP000036403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole {ECO:0000313|EMBL:KMQ96463.1};
RA Konorov E.A., Nikitin M.A., Kirill M.V., Chang P.;
RT "Lasius niger genome sequencing.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + Xaa-L-Pro dipeptide = an L-alpha-amino acid + L-proline;
CC Xref=Rhea:RHEA:76407, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869,
CC ChEBI:CHEBI:60039, ChEBI:CHEBI:195196; EC=3.4.13.9;
CC Evidence={ECO:0000256|ARBA:ARBA00043793};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the peptidase M24B family. Eukaryotic-type
CC prolidase subfamily. {ECO:0000256|ARBA:ARBA00043990}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMQ96463.1}.
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DR EMBL; LBMM01001351; KMQ96463.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J7L1J1; -.
DR STRING; 67767.A0A0J7L1J1; -.
DR PaxDb; 67767-A0A0J7L1J1; -.
DR OrthoDB; 4051655at2759; -.
DR Proteomes; UP000036403; Unassembled WGS sequence.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IEA:InterPro.
DR CDD; cd01087; Prolidase; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR007865; Aminopep_P_N.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR010622; FAST_Leu-rich.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR48392; -; 1.
DR PANTHER; PTHR48392:SF2; PEPTIDASE D; 1.
DR Pfam; PF05195; AMP_N; 1.
DR Pfam; PF06743; FAST_1; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SMART; SM01011; AMP_N; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590};
KW Reference proteome {ECO:0000313|Proteomes:UP000036403}.
FT DOMAIN 1..88
FT /note="Aminopeptidase P N-terminal"
FT /evidence="ECO:0000259|SMART:SM01011"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KMQ96463.1"
SQ SEQUENCE 878 AA; 98794 MW; AFE4172214B2D82F CRC64;
ESFFQWCFGA EEPGCYGALD LDNGVSILFV PRLPPEYAIW EGKLYTLDDF KERYGVDETY
YTDEIARVLK EKRARLLLTL SGRNSDSGLL AHEAIFDGIG EFKVNNSILY PEICECGTQL
TQTNIFVQEG THIQEVPLIV RKITNIEALF GNGNKEDTSV SNKNKKSAII YKENIPPTRS
TNTSVIKTEP PKHSISIETN EGTAILFCPN IERLRNTDIE QVLDTIKSET STDKGMYSSL
EGKTADEINC RIALQNLKKM IELENGWYRY RKTLSSGQSS AEVVNRNIIL RQLVHLIVKS
RDSEMILQGL RTLKRDRFSP STNVYKDLMC NEVMIRATDG KFTVSQLIRA VKILASFRDS
KYRNCVDMLW IGLACREQDI KSDLLVPLFR SLKYFQRSKD MIQIILEKKL SEQWLKLSGT
QMANILDCLH GKEPSKGYLS SASKWAGVSM TTSTEKDLVN FISGLRAKKY IDENIEQAMA
RYVTTRGTET RDPNLIASVM DYCKDLKIRN PYILAECGKY FIRHGTEISP TLLSSVLTPF
GLLNVQPPDP TEFWKMFDEV MSARFTDLKL NDALDILLSC MYLEKYPVNR VIKSPKEIEV
LRYVCKISSE AHKVIMRSMR PGIPEYRAEA WFLHYVYSTG GCRHVSYTCI CGSGHNSSIL
HYGHAGAPNN KVIQDGDMCL FDMGGNYCGY AADITCSFPA NGKFTEDQKL IYNAVLKARD
AVIAAAKPGI TWTDMHLLAN RVTLTSLKEG GLLVGDVEDM VRAGLNEVFQ PHGLGHLLGL
DVHDVGGYLP GHPERSKEAG VRKLRTARTL LAGMVLTIEP GCYFIDCLLD AALANPDQSK
FLVQKQLQRF RGFGGVRIED DVLITETGVE NMTDVPRT
//
