ID A0A0J7L4N1_LASNI Unreviewed; 1270 AA.
AC A0A0J7L4N1;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Cd109 antigen {ECO:0000313|EMBL:KMQ97464.1};
GN ORFNames=RF55_2201 {ECO:0000313|EMBL:KMQ97464.1};
OS Lasius niger (Black garden ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Lasius; Lasius.
OX NCBI_TaxID=67767 {ECO:0000313|EMBL:KMQ97464.1, ECO:0000313|Proteomes:UP000036403};
RN [1] {ECO:0000313|EMBL:KMQ97464.1, ECO:0000313|Proteomes:UP000036403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole {ECO:0000313|EMBL:KMQ97464.1};
RA Konorov E.A., Nikitin M.A., Kirill M.V., Chang P.;
RT "Lasius niger genome sequencing.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMQ97464.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LBMM01000801; KMQ97464.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J7L4N1; -.
DR STRING; 67767.A0A0J7L4N1; -.
DR PaxDb; 67767-A0A0J7L4N1; -.
DR OrthoDB; 2970602at2759; -.
DR Proteomes; UP000036403; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000036403};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1270
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005290458"
FT DOMAIN 401..544
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 510..595
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1121..1210
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1270 AA; 141924 MW; 34802BD5F9A1ECF1 CRC64;
MEYAWLGILV LSGIISNVAA ESFYTIIAPK VVRPDSEYHV AASVTGVSTP STIYVELTGE
LDAGRVFNIS RTVVVEPYST KILRLDIGET TPGRYKLTAR GLSGIDFYKS TDIEYVHKSY
SVFIQTDRAI YKPGHKVMFR CIILDSRLRP SIVGPTDVYI IDGDGNRIKQ WTRPSVAHGI
FSSELELSHS PVLGNWKIIA NVGDQTFEKE FEVAEYVLPN FEVTIDSPKH VQFKESKVMA
TVNARYTYGK PVKGEATITA YPDIFSGVIQ PIFQQPVRKV VPIDGKVTVD FDILSELRLT
DEYERPIMID VVVEEALTTR RQNASIQVTL HKHKYTMELI KTSEYFKPGL KYTAFLKLTN
HDGSPVQDTK NDVLIAYGYT YDRSAYLNVT RMLDQNGMVQ LDLYPPKAND NISFPLNIEV
NNYIEIEVNS TAPLKYISYE VLGRGDILDA GSIYVQDKST TTFKFLATYV MAPTAHVIVY
YVRTDGEVIA DSLDVELTGI LQNFIDLKVT PGEVMPGESV NLVISAKPNS FIGLLGIDQR
SILLKSGNDI SYLKVFRPFF ISMDLPYSVI RGEIVGIQIV VFNYMNKDLT AEVLLNNEGQ
QFDFAEVSNE VHDVPKLELY RRKKVDVKAN SGSSVSFMII PKELGYIFIK ATANSVLAGD
SVEHKLLVNA EGETQYKNEA VFLDLRNVEN AGANVTINIP NNAVPGSESI HISAVGDILG
PSIPNLANLI KMPFGCGEQN MLNFVPNIVV LNYLKNTNQL TQAVQSKALK YLDTGYQQEL
TYRHTDGSFS AFGMSDPSGS TWLTAFVVKS FKQAADYIPV EDRIINEALE WLSNNQAANG
SFPEVGKVSH RDMQGGAAKG LALTAYTLVA FLENEDSVEK YRNTINKAVD YIVRNIEGLN
DTYALSLCAY ALNLAKHPYE TSAFNFLESM AMTKQDVKWW SKPIPKDDKN PHYSLPRSVD
VEMTSYALLS YLRRNLVADA IPVMKWLVKQ RNTEGGFAST QDTVIGLQAL AKLAEKLSKD
TSSVRIAFKY GKEGQGYMNI NSGNSMILQK QILPTKTRSV NITASGKGFV LVQVSYQYNL
NVTGAWPLFT LDPQVDKNSN VNHLQLSICS GFVPTKEANE SNMAVMEVSL PSGFTVDRDS
LPSLELSSHV KRVETKNGDT MVVLYFDKMI KEEYCPTVSA FRTHKVAKQK PVPVSIYDYY
DSSRRARVFY EARRTTLCDL CEDEDCEDIC VSKPGKQKDN ATVSAASHIY TCVYLQLTFF
SFYLLLHKYL
//
