ID   A0A0J8QRL4_COCIT        Unreviewed;       175 AA.
AC   A0A0J8QRL4;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Lovastatin nonaketide synthase {ECO:0000313|EMBL:KMU74735.1};
GN   ORFNames=CISG_00665 {ECO:0000313|EMBL:KMU74735.1};
OS   Coccidioides immitis RMSCC 3703.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU74735.1, ECO:0000313|Proteomes:UP000054559};
RN   [1] {ECO:0000313|Proteomes:UP000054559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
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DR   EMBL; DS268119; KMU74735.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J8QRL4; -.
DR   STRING; 454286.A0A0J8QRL4; -.
DR   Proteomes; UP000054559; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR013968; PKS_KR.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR   Pfam; PF08659; KR; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054559}.
FT   DOMAIN          84..175
FT                   /note="Ketoreductase (KR)"
FT                   /evidence="ECO:0000259|Pfam:PF08659"
SQ   SEQUENCE   175 AA;  19359 MW;  B96572B51298D7CA CRC64;
     MTRNGLEPRP TEIPLMDQFK CAAAGALSEL HSGKQVSRPV MNIGDILTRS TTPETPVVNW
     SNTVDIPVRL ASVDKQMHFA ADKTYVFFGL SSDLGQSLCN WMAYHGARNL ILTSRTPKVD
     PRWLSEMESI GVRVKVYSKL TVDSDITDKT SLEALVAEIR REFPPIAGIM HGAMV
//