ID A0A0J8QSS1_COCIT Unreviewed; 702 AA.
AC A0A0J8QSS1;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CISG_04929 {ECO:0000313|EMBL:KMU75526.1};
OS Coccidioides immitis RMSCC 3703.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU75526.1, ECO:0000313|Proteomes:UP000054559};
RN [1] {ECO:0000313|Proteomes:UP000054559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS268141; KMU75526.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8QSS1; -.
DR Proteomes; UP000054559; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3730.20; -; 1.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF98; DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_2G07880); 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054559};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 400..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..657
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 76814 MW; 212C8BF7A065C994 CRC64;
MPEQLLHAIS LAARAGGLAG DVGSRPPVFK AVGISLAVAS GLFIGVSFVL KKVGLLRANV
KYNEEAGEGY GYLKNFYWWA GMTLMILGEI CNFVAYAFVD AILVTPLGAL SVVVTTILSA
IFLKERLSFV GKVGCFNCII GSVVIAMNAP QQSSVSNIQD MKRYVIRPVF LTYAGVIIVG
CTVVAIWAGP RYGKRSILIG ALSVVATQGL GAAIIAQISG QPQFKEWFLY VLLGFVIITL
LTEIIYLNKA LNVFNAALVT PTYYVIFTSA TIITSAVLFQ GFKGSPISIT TVVMGFLQIC
TGVVLLQLSK SAKDVPDAAI FKGDLDQVRE VAEQEQPESE PKADAIRGTA AIIRRISTPR
QKMERDEALR YQSERKLDES WSPGENEIIE WDGLRRRRTV LSVGPTATPR RTKTPRPPLG
MSRFPEDDED SEPKSRTGRS FLDSFRSRTS SGRSSRKSSE NSQSTETRMC SIELESIHDR
SRRTSMIPHD RSRTPSPTSS ILESMNEKPF GESNMSYSRR SRRSSSTSSS SSSEYHRSFD
RIPSYVKGDD HLYNVVRTSA SDPFSVTDQD NPAGISELRV PHNPDNERSL TAGTDNVAHP
PASYQRPLVQ GRDLPPIPVE TTRSDGTSLF DPPQNVYTTN PNISIPPLPP DPRSIPSAPP
SISSDMDSVE EEILEDHDDR DRAGSRNRGP TSLSSSNGVA FI
//
