ID A0A0J8QSX7_COCIT Unreviewed; 953 AA.
AC A0A0J8QSX7;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA mismatch repair protein MSH3 {ECO:0000256|ARBA:ARBA00019000};
DE AltName: Full=DNA mismatch repair protein msh3 {ECO:0000256|ARBA:ARBA00022151};
GN ORFNames=CISG_04412 {ECO:0000313|EMBL:KMU75125.1};
OS Coccidioides immitis RMSCC 3703.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU75125.1, ECO:0000313|Proteomes:UP000054559};
RN [1] {ECO:0000313|Proteomes:UP000054559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA
CC mismatches thereby initiating DNA repair. MSH3 provides substrate-
CC binding and substrate specificity to the complex. When bound, the MutS
CC beta heterodimer bends the DNA helix and shields approximately 20 base
CC pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to
CC 13 nucleotides in size, but can also repair base-base and single
CC insertion-deletion mismatches that occur during replication. After
CC mismatch binding, forms a ternary complex with the MutL alpha
CC heterodimer, which is thought to be responsible for directing the
CC downstream MMR events, including strand discrimination, excision, and
CC resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch
CC repair functions. {ECO:0000256|ARBA:ARBA00025373}.
CC -!- SUBUNIT: Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a
CC ternary complex with MutL alpha (MLH1-PMS1).
CC {ECO:0000256|ARBA:ARBA00025902}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR EMBL; DS268137; KMU75125.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8QSX7; -.
DR STRING; 454286.A0A0J8QSX7; -.
DR Proteomes; UP000054559; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054559}.
FT DOMAIN 822..838
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 513..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 106530 MW; 39F2B15EBDA6267E CRC64;
MMRAIVRNAR TLRVPPFRHS PTSTFCALSG HEVFSRSVIR QSSCRGAKTK ASIKLKDLAQ
GRLGSLEPPL TATNDSPQYP SVIQGAKNNM LKFKNCVLLT RVGGFYELYL EQAEEFAPLL
NLKLACKKTS GGSVPMAGFP FYQLDRFLKI LVQDLQKYVA ISEEFTNNIT EKAKSGGLMF
DRKVARIVTP GTLIDEKFMD HYENNFLLAL YVNTSDMQKE TKAMARPSPD QLFSSSHSHP
VGLSWLDLST GDFFTQYTTR LMLPSALSRI GAKEIILDER LNDSLKQEMQ NLVGQDHRLL
TCFRSQDIKP MSDWSECFET PIPRELAATF TVEETAACHI LLEYVQVQMQ GVGVKLQAPR
RKHLEETMAI DRNSLKGLEI LETARDGLGK GSLLHAVRRT STKSGARLLR DRLTSPSASL
PVINERLDLV SEFIEDIELE ESITSLLKRS YDAQRLVQKF SLGRADADDI YAIKGYRCIK
PNKTIDEEAL LRKQRMEEED AADAAALAHE VIANEGSPED LESMPKRVKS QRTGKSKDLS
DSEADEQNSW IMQRDASVTL QRLHKSLESL YAEKASLTDR LRKDSKTASL CLKWTPGLGH
IVHMKGSKAM AQSLDVLGVH RTVSSSKSTR SFHLPSWTKL GARIDEMKLQ IRSEEQRIFK
SLREDVIRNL VKLRRNAAVL DELDVACSFA SLAREQRLTR PILNMGYSHK IIGGRHPTVK
LGLEEKGRPF VNNDCFIGGQ ERIWLITGPN MAGKSTFLRQ NALITILAQV GSFVPAEYAE
LGMVDQIFSR IGAADDLFRD QSTFMVEMLE TAAILKHASR RSFVIMDEVG RGTAPEDGIA
IGFACLQHLH DVSKCRTLFA THFHSLAEMT SNFGNLGRYC TSIVEDTDGS FSFIHKLQRG
VNRNSHALKV ARLAGVPQSV IDVAEAVLND ISLMSSQPEA RERERSAIVS VKS
//
