ID A0A0J8QWF9_COCIT Unreviewed; 1180 AA.
AC A0A0J8QWF9;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 {ECO:0000313|EMBL:KMU75663.1};
GN ORFNames=CISG_04837 {ECO:0000313|EMBL:KMU75663.1};
OS Coccidioides immitis RMSCC 3703.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU75663.1, ECO:0000313|Proteomes:UP000054559};
RN [1] {ECO:0000313|Proteomes:UP000054559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; DS268142; KMU75663.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8QWF9; -.
DR STRING; 454286.A0A0J8QWF9; -.
DR Proteomes; UP000054559; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF145; ATP-DEPENDENT RNA HELICASE DHX29; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF05773; RWD; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50908; RWD; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:KMU75663.1};
KW Helicase {ECO:0000313|EMBL:KMU75663.1};
KW Hydrolase {ECO:0000313|EMBL:KMU75663.1};
KW Nucleotide-binding {ECO:0000313|EMBL:KMU75663.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054559}.
FT DOMAIN 415..515
FT /note="RWD"
FT /evidence="ECO:0000259|PROSITE:PS50908"
FT DOMAIN 655..821
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1180 AA; 130745 MW; A54EAF384D0CBC55 CRC64;
MAPKRGGASR GKSNNPPKQQ PKEISIDDFV AGGDSKNAKG KSKGQKAGGE SSAGGETEQP
KKPTVRSIIG GASWTGKLPV NMLSEHCQRQ KWEKPEYTMF KSPDGFISSV ILKKTNPKTK
ETVTLPPMRF PQAHSKLAAQ PTALEARHFA ASYALFRVCS MQNLHMMMPP TYRDLWKKEF
AQLKVDDVKA GKAWMYESDP FTAQQEHQNA VADSTKRKAE QDSKGKLKQK EPLVQLGSAG
GDNKPPPGIR WQKAPKIEMG EKTRRKIEDL VRQSALWNPY GVKIHDSEKK RIVDDFSNLG
FRKSHVEEAV AECKDREEAL EWLLIHVPED DLPKWSLPEG YSAGVTLASG DLARESKIKR
LALAGYSTDL CAKALEDNDD DELKAAECLQ SLLVDSGDFF PSGELPESEC DAWEEENQTL
EAIYGEKYKK LSSNKCEIIS DQLHSQYAVA YQFQKPAIAS YPTCPLVLTI SSKKIPAYIR
LSAIREAIQY AHENLLGGPM VFNLVDWLEE NIPRILENPG KLRNISIDTP SRVVNEHARP
ASLKGSRTLP HRTKVQGGAQ QNAGIREAWE SGHRSPEQLK MITARKCLPA WAMQDAIVQA
VNTYQVVQLT HLNQASVVSN WDESPGTLDE REELSAGKAL QRLGKGISYD LIAATVRHID
AELQDQPGGI LIFLPGTMEI DRCLATMRDF SFAHLLPLHA SLTPNEQKRV FSAAPKGKRK
VIAATNVAET SITIEDVVAV IDTGRVKETR YSPADNIVRL EETWASQAAC KQRRGRAGRV
RNGTCYKLYT RNAENNMASR PAPEIQRVPL EQLCLSVKAM KGIEDVAGFL AKTLTPPDTA
AVKGAIGTLH RIGALDNDQL TVLGRYLSII PADLRCAKLM VFGVIFGCLE ACVSIAAILT
AKSPFASPKD QRDEAKAARA SFSTGDGDLL IDMVAYQQWS ERVKLQGYRR TLAWCNDNFL
VPQTLRDITS NRAQLLTSLK EVGILPVGYR GDGELSERRW NRHNTNWQLL RALIAGAFNP
QVASISFPEK RFAASMTGTI EVDPEARTIK YFNEENGRVF VHPSSALFDA QSFSGAAAYV
SYFSKMATSK VFVRDLTPFN AYSLLLFGGP ITLDTHGRGL VVDGWLSLRG WARIGVLVSR
LRMLLDKALA RRLDNLDLDI SEDEVVEVVR HLVLLNGQDH
//
