ID A0A0J8RCF3_COCIT Unreviewed; 860 AA.
AC A0A0J8RCF3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Homeobox and C2H2 transcription factor {ECO:0008006|Google:ProtNLM};
GN ORFNames=CIHG_00383 {ECO:0000313|EMBL:KMU82602.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU82602.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
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DR EMBL; DS016981; KMU82602.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8RCF3; -.
DR STRING; 396776.A0A0J8RCF3; -.
DR VEuPathDB; FungiDB:CIHG_00383; -.
DR eggNOG; KOG0773; Eukaryota.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR PANTHER; PTHR11850:SF383; ZN(II)2CYS6 TRANSCRIPTION FACTOR AND HOMEOBOX DOMAIN TRANSCRIPTION FACTOR (EUROFUNG); 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 157..220
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 377..405
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DNA_BIND 159..221
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 139..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 94754 MW; ECDC30CC63EDE36F CRC64;
MEYFDFDQAA RDIDTASNCP EIDHQDFDAL MNDDNVVVSA TDALNDVAEG EKGWEPSFKL
GGPWPMYRAP EPCFFCRSMG LDCFVAQRGV LQNRCTCCIA LYRQCSFTNA EPQQKCLETL
HVVGEDSYVP TGSLTGKRAL KSYRGPSTGT LLEEPEQRGR KSGARFPKEA VRVLKSWLSE
HTAHPYPTDE EKDALKAKTG LRRSQISNWL ANARRRGKVR PSPRHPSPHP TGVPIPGKEL
PPGVDFADLN PLERWKHSPP ENEAASARDI IQAMATAPFH PNGSNDTSGP VRSNSRRTGS
SNGDSSFSNV RPAGSWSSYS LDTTQSSVSD MSFASVFSHR SSRASFGSMD TRERRRRRHK
SAIGQNPFQK SRAARIYQCT FCTDSFATKY DWQRHEKSLH LALDKWTCAP QGGVILENGE
SVCAFCRYLN PDETHLESHN YTTCQEKSIQ ERTFYRKDHL NQHLRLMHNV KLGSWMDQWK
SATTEVKSRC GFCSATFTTW KDRVDHLAAH FKAGAEMRQW KGDWGFESCI QRCVENSMPP
YLIGEERNTL NPWVAQVPSL SAAKKPNAST AGTSAAQIPV PTDASCFKRL EVELSAYIGR
LAAQGTVPTD AMIQAEARNT IYGSDDPWNQ TCADNPTWLA LLKRDTGIYD LPGTQNIQLD
DLGMQPPFAA NGGLRQAPKH SLRTTPPCSG SSGFQSPALP SSGFHSSGPS HRGSHAGSLA
GSVDFSAGGL GQGSLGGLPS STLGGTLSSS APVSMDNDPF IQMGFDADFL QRLDDDYEDI
GHDLDDLHLE KFGLGDSAGF HDLGFNDTTF NMTATSAPDQ NPLASKLPTS MSYEARYQNV
FDHSVAFSEP RASEFRDFGR
//
