ID   A0A0J8RF74_COCIT        Unreviewed;      1078 AA.
AC   A0A0J8RF74;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Mitotic spindle checkpoint component mad3 {ECO:0000313|EMBL:KMU83587.1};
GN   ORFNames=CIHG_01370 {ECO:0000313|EMBL:KMU83587.1};
OS   Coccidioides immitis H538.4.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU83587.1, ECO:0000313|Proteomes:UP000054563};
RN   [1] {ECO:0000313|Proteomes:UP000054563}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
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DR   EMBL; DS016983; KMU83587.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J8RF74; -.
DR   STRING; 396776.A0A0J8RF74; -.
DR   VEuPathDB; FungiDB:CIHG_01370; -.
DR   eggNOG; KOG1166; Eukaryota.
DR   Proteomes; UP000054563; Unassembled WGS sequence.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   Gene3D; 1.25.40.430; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR015661; Bub1/Mad3.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR013212; Mad3/Bub1_I.
DR   InterPro; IPR012572; Mad3/Bub1_II.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR14030:SF4; BUB1 KINASE, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR   Pfam; PF08311; Mad3_BUB1_I; 1.
DR   Pfam; PF08171; Mad3_BUB1_II; 1.
DR   SMART; SM00777; Mad3_BUB1_I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51489; BUB1_N; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054563}.
FT   DOMAIN          63..222
FT                   /note="BUB1 N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51489"
FT   DOMAIN          866..1078
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          233..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          610..640
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          888..917
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        613..635
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1078 AA;  119147 MW;  4CA3C43DF4C0A493 CRC64;
     MSGSGDLINF DVIESQKENI QALPTGRSAK ALVAAISPLN SGNYSRCSPD DTQSVNDSIR
     AEYERELEAV GESDDPLDIY DRYVKWTLDA YPSAQATTKS GLLPLLERAT KTFLSSSHYK
     NDPRYLRLWL HYIRLFSDAP RETFAFLSRH GIGEGLALFY EEFAAWLEGA GRYAQAEEVY
     KMGLEREARP MERLMRKFGQ FQDRMEQRPG NPDGPSSPAL PTVRPALAAK VDPFASARPP
     PENPQEESRT RGIGGGTKTR SGKPKMAIFS DADSGAMGPS PAAAPTKGWD SIGSIRERKK
     ENLIEPRPWV GETLKAGKKT NPKQKMAIFR DPNSISNNAK AVPPENLPQN QRERVDARTG
     KVERVFVNLA AVYPDPENPA LEMSLDELRA LHRGWMDKDW SKQKKGALKE VSGNKSKHPV
     VSAGKANQPD KSLSAQLQNK LVIHNDRQPA KENGEAVEVF RDAKEGKPKK IKVREIKGET
     QTVKTKLDSP TGPKLKRKNA SEPTMTFHTR AATDEIYSIF NQPLKAELQA AEHPDSICGS
     DYEDDDYTSA GESTATGRIS AINSEFGDDE TSAFERTQDI NGESEFDDQT KTGVSEWTEF
     SPAEHISQFH SEHREGIQGS GSETNISSSS QGHFQDPAHF LPADENENAM YSSSSDRLKE
     HRFVPIQPED YNPPTGPYRD PYTVAQNRLP FMTPILEQTE SSLASTIFRE KLSTKTPSKM
     GKPFCPSATP AIPEVDGSEL LGSPFQDYTQ ANDAVLKYTR EIISPSKIGI PFQPPAPKFP
     VFKGNGHVII TEHQCNPMER AIQEKILRSV RPALHTYEGY YDHKIEVGGN APEIKRYFKS
     LVKGSKGNGG DKSPAVPPVL CFQVRYAIKR ELGEGGFAPV YLAESVDSPD TFSDSDDEND
     GYELSPCTPS PKGKELKTIR NSDRGSLEAV KVETEPPSAW EFYMLRTAHT RLSSTSLHRR
     AADSIVLVHE LHHFKDETIL VEDYRGQGTL IDLINVMRAE CKAGAGSTDS GLDEAVSMFF
     AIELFRTVES LHACGIIHGD LKADNCLVRL DEAGGAPISL LDTDLNGIDY SPSERMAG
//