ID A0A0J8RHL2_COCIT Unreviewed; 844 AA.
AC A0A0J8RHL2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=DNA repair protein rhp42 {ECO:0000313|EMBL:KMU84106.1};
GN ORFNames=CIHG_01892 {ECO:0000313|EMBL:KMU84106.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU84106.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; DS016984; KMU84106.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8RHL2; -.
DR STRING; 396776.A0A0J8RHL2; -.
DR VEuPathDB; FungiDB:CIHG_01892; -.
DR eggNOG; KOG2179; Eukaryota.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054563}.
FT DOMAIN 516..573
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 575..638
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 645..719
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..814
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 95874 MW; 18FB19B9AD6AD48B CRC64;
MPPFVPRKDH STQDTPSKRG LLEALDTPPK SATLEKLKAQ KISLESDSSS LSSLSSSDLE
NSANSAGVDD DDDDEEVNWE DVLGAPSGSN AAPTPELRDL DITIQKNHVS LTEPLGGKKG
PSKIERFIRI QTHCMHVQFL LFHNAIRNWW INDPEIHEIL REKLPEGIKK EIQRWRIAAG
LETPKPTPKE SSKKRKRDRD WTEDSSYVEP NRPDLSRGDP TIHLLKVLAA YWKKHFKITS
PGLHKRGYRP ASVLEEELRA FNRGEEDENR FGEKIQDLNE FREHARRLYG SRDVGSQLFT
ALLRALGLET RLVASLQPIG FGWAKIEKYA SADETAPNSP VESEESSLDE ELPPRPKGKS
KISNKRQQLA DGDSPFPTYW SEVESPVTQE IIPVESLILP NSVAMTPELL AAFEPRGAKA
EKAKQVIAYV VAYSPDATAK DVTIRYLRRQ TWPGKTKGFR IPVEKPVEIE LSTGPYVYDW
FKATMRGYIR PRDKRTTVDE KEDLSLVAKQ PEKKAPKEGD TLQSLKASKD FVLERFLRRE
EALRPGASHV RMFISGKGAK QKEEKVYRRS DVQKCLSAES WHKEGRRIKL GELPLKLVPI
RAVTRNRKLE VDRMERETGE KPKQGLYALH QTEYIIPDPI QDGIIPKNEY GNIDCFTPWM
VPKGAVHIPW PATVRVCKKL RVDYAEAVIG FEFSSKMAVP IIQGVVVAAE NEDLVKDAWR
AEDAQRRERE RLKQEKLILT TWRKFIMGLR ISERIQEEYG DTIEMESQNP FVNQRNIIPS
DVQPVDRDEA DYHDGGGFLV PGEDEPEHDQ LGIQAQPRKV EGSREVPIAL DNDTSEELSD
IESV
//
