ID A0A0J8RKG2_COCIT Unreviewed; 318 AA.
AC A0A0J8RKG2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Dcs1p {ECO:0000313|EMBL:KMU85312.1};
GN ORFNames=CIHG_03096 {ECO:0000313|EMBL:KMU85312.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU85312.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SIMILARITY: Belongs to the HIT family. {ECO:0000256|ARBA:ARBA00010208}.
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DR EMBL; DS016988; KMU85312.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8RKG2; -.
DR STRING; 396776.A0A0J8RKG2; -.
DR VEuPathDB; FungiDB:CIHG_03096; -.
DR eggNOG; KOG3969; Eukaryota.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR Gene3D; 3.30.200.40; Scavenger mRNA decapping enzyme, N-terminal domain; 1.
DR InterPro; IPR008594; DcpS/DCS2.
DR InterPro; IPR036265; HIT-like_sf.
DR InterPro; IPR011145; Scavenger_mRNA_decap_enz_N.
DR PANTHER; PTHR12978; HISTIDINE TRIAD HIT PROTEIN MEMBER; 1.
DR PANTHER; PTHR12978:SF0; M7GPPPX DIPHOSPHATASE; 1.
DR Pfam; PF05652; DcpS; 1.
DR Pfam; PF11969; DcpS_C; 1.
DR PIRSF; PIRSF028973; Scavenger_mRNA_decap_enz; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR SUPFAM; SSF102860; mRNA decapping enzyme DcpS N-terminal domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054563}.
FT ACT_SITE 245
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR028973-1"
SQ SEQUENCE 318 AA; 36382 MW; ECCFF5E9F332D086 CRC64;
MSGKSEAESL IPRFRIERLL NQDQNDRRIS ILGSIDDQPG VLIIERAAFV ADIGSLKAFH
AALGNVTNLG ANDIYRWYMA SSGQNHVNPP DLKLNLIWPC TEQHVLKYSA QNVRMVTETP
EIYQKYVRPY MQEKRGNGRL NWVFNIIEGR KEQEDVLHRE SDPEEGFLLL PDLNWDRKTI
GTLRLLALVE RRDIWSMRDL RKSHVVWLKQ MRQKLLEAVV KVYPELDTDQ LKLYIHYHPT
YYHLHIHVVN VMLEAGTTQS TGKAFGLENL ISQLDAMAGD ADASMADVPV SFFLGESSEL
WTSIFGPLKR GETPSSGH
//
