ID A0A0J8RKK4_COCIT Unreviewed; 808 AA.
AC A0A0J8RKK4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Chloride channel protein 3 {ECO:0000313|EMBL:KMU85357.1};
GN ORFNames=CIHG_03141 {ECO:0000313|EMBL:KMU85357.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU85357.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS016988; KMU85357.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8RKK4; -.
DR VEuPathDB; FungiDB:CIHG_03141; -.
DR eggNOG; KOG0475; Eukaryota.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF3; CLC CHANNEL; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 74..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 88815 MW; 64B4E4AB395CC1D3 CRC64;
MSKNHSRANS QATKFGPNGA VEWSNSPLSQ EETRFSDNRV WYDQFTSTDW VHDTIADGIR
LRELRSRRDI RGRFLAWLDG AQGWILVAVI GIVTACFAYF VDVTERALYD LKEGFCTDNW
FSSKHHCCLG EDDCSSWSTW ADIFRLPKAD KAWVDFLAFV AWAIILATAS CLLTLLTKTV
VPSSISLSTL DEDLAAGGAG SSDRNDGKAG SDASVTDFEE SAPPMVYYSA AGSGVAEVKV
ILSGFVIHGY LGMKTLIIKT LALVLSVASG LSVGKEGPYV HIATAIGNIC CRIFSKYQHN
DGKRREVLSA SAASGVGVAF GAPIGGVLFS LEEVSYYFPP KTLFRTFFCC ITHIMVLNAY
MLQVAALSLK FLNPYGTGKI VLFQVHYVSD WEIFEVALFM ILGALGGAAG ALFIKASKIW
AQSFRKIPAI KRWPMLEVIL VALLTGIMSW WNRYTKLAVS ELLFELASPC DYAQASNTGL
CPTKEEIPQV IRYLIIAFVI KAFLTIVTFG IKVPAGIYVP SMVVGGMMGR IVGHIAQYFV
VHYPNFFLFG SCPSSRGPLA CVNPGVYALI AAGSTMCGVT RLSVTLVVIL FELTGSLDHV
LPFSLAILCA KWTANAMEPL SIYDLLTDMN SYPYLDNNLN PITDAELGEI VPSVRKSRII
DITESPLVPA SELRTKLDIL LRGGELDSGL PILRDSILVG FIPAPELEFA LDKLETEDAM
CLMSMHSTWA GWSSVEEQEG LEPTDFTPYI DPSPVALDVH SPINLVYQCF VKLGLRYMCV
LRDGKYAGLV HKKWFVKFMK ETHKSEEA
//
