ID A0A0J8RL19_COCIT Unreviewed; 424 AA.
AC A0A0J8RL19;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Mapkkk cascade protein kinase regulator ste50 {ECO:0000313|EMBL:KMU85835.1};
GN ORFNames=CIHG_03363 {ECO:0000313|EMBL:KMU85835.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU85835.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; DS016990; KMU85835.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8RL19; -.
DR STRING; 396776.A0A0J8RL19; -.
DR VEuPathDB; FungiDB:CIHG_03363; -.
DR eggNOG; ENOG502QQYX; Eukaryota.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01786; RA_STE50; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR24135:SF28; LD13733P; 1.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:KMU85835.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW Transferase {ECO:0000313|EMBL:KMU85835.1}.
FT DOMAIN 10..64
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 305..378
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 140..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..127
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 141..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 424 AA; 46129 MW; AFF2E879F6A74CB6 CRC64;
MAAGIFPFSS DYKTDLFVSG YIVENEIVGE ALIALRHDEL KELGISSVGH RLTLLKSVYE
IKVKQGVPFD SDHYVPLSAE QSNAKEVATQ EDVALLIRTI RKRDERLAAA EAELRKLADD
YRRLREELLP VFKMAKDRSQ PLPYQPTSSF GGSTLLSDQC IHDQPATSPS INQPEKTGTS
LSSSPTHIPQ SIPEGRTYTD TSTLDPSAAA MAASSHLTAS MNGAQPSPKG IPSPTSPASF
YPQQTLASRS YSRETSSINR SYDHPEDPQS QQRQDRPTPN HPNSNSNPPS SRNPNDAAGP
SVEIFKSFRV SMDDPCYKVL PAALKKYNIH EDWRHYALYI VYGDQERCLG LEEKPLILFK
QLAGDGQKPM FMLRRQTPIS DSTATNIYPG GGIGIPPGSA GIEGGGGGIG RPQPGAIQLP
GGVL
//
