ID A0A0J8RMP0_COCIT Unreviewed; 400 AA.
AC A0A0J8RMP0;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Rho1 guanine nucleotide exchange factor 1 {ECO:0000313|EMBL:KMU86087.1};
GN ORFNames=CIHG_03874 {ECO:0000313|EMBL:KMU86087.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU86087.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; DS016991; KMU86087.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8RMP0; -.
DR STRING; 396776.A0A0J8RMP0; -.
DR VEuPathDB; FungiDB:CIHG_03874; -.
DR eggNOG; KOG4305; Eukaryota.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054563}.
FT DOMAIN 302..400
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 45641 MW; 66D3FDC20B3161E3 CRC64;
MSLSSYTSDR DHAQTISSGR VIPNRRRDSG MERDRADRMD RRPMERPPSD QIPGLPEITP
PHDPHSRIRH PSESSINSRT LSMASTVAAD RNNSLQTPNS VKSGHSAPAT VTAHRSRTPL
VYPALLSRVA AVFKERVSIG ERIKNDLAYT NAFTGAEAVD LLSYIIKTTD RNLALLLGRA
LDAQKFFHDV TYDHRLRDAP GELYQFRETM GEESPISEVN GVFTLLTECY SPTCTRDQLC
YSIACPRRLE QQARLNLKPH PGLRTSASRG SLHDQDESED QKLWINMVPK EVADSIDDRE
KKRQEIIFEV MYTERDFVKD LEYLRDFWMR PLRSAHNTNL SPVPEHRREK FIRTVFGNVL
EVLSVNSRFS EALNARQKES HVVHSIPLVA GECCQVHERR
//
