ID A0A0J8RPB3_COCIT Unreviewed; 673 AA.
AC A0A0J8RPB3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Nucleolar complex-associated protein 3 {ECO:0000256|PIRNR:PIRNR028977};
GN ORFNames=CIHG_03367 {ECO:0000313|EMBL:KMU85839.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU85839.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- FUNCTION: Required for synthesis of 60S ribosomal subunits and the
CC transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
CC {ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797, ECO:0000256|PIRNR:PIRNR028977}.
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DR EMBL; DS016990; KMU85839.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8RPB3; -.
DR STRING; 396776.A0A0J8RPB3; -.
DR VEuPathDB; FungiDB:CIHG_03367; -.
DR eggNOG; KOG2153; Eukaryota.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; NUCLEOLAR COMPLEX PROTEIN 3; 1.
DR PANTHER; PTHR14428:SF5; NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW Ribosome biogenesis {ECO:0000256|PIRNR:PIRNR028977}.
FT DOMAIN 115..207
FT /note="Nucleolar complex-associated protein 3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07540"
FT DOMAIN 469..660
FT /note="CCAAT-binding factor"
FT /evidence="ECO:0000259|Pfam:PF03914"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 75146 MW; 3DF1783F41A5DB4B CRC64;
MAPGHAAKRR RLSPTGKTTA PSTLNSFYAN ASQWDLEQDY ERRPRKGSKK DKERTRLPIK
TAEGAIEHVE EPAHSEPESL SPFDSDEESE DDAPATTEAV EQPVSQVPPK LQIIQAKEEL
AKIATLINED PEEHIDLFKK LAEMVKASSL LAVKKLALAT QAAVYRDVIP GYKIRPLGDA
ELAVKVSKEV RKVRNYEQAL LSGYRNYVQD LISFSRSKHD DSLKSVAINC AYSLLDAVPH
FNCRQELLKI LVSQLSRRQL DADSIKSREA LKEIFSNDED GIVSMEAVSL LAKMMKAKDF
NIHPSVLDTF LHLRLLSEFS SKGSKDGIDR NEDEVNTYKG KKIKEKREFR TKKTRKLLRE
QKAAAKDLRE ADALVKHEQR DKMQAETLKS VFTTYFRILK LRSASLMGAT LEGLAKYAHL
INQDFFGDLL EVLRELISES SHPDQTDEET NGNADQENAI SRNTTREVLL CSTTAFALLE
GQDASKAASS LHLDLSFFIS HLYQSLYPAS LNPDIEYNPS KSLRLPDPGS TNAGADDISG
KDKKVNFQTP TVLLLRCLQP ILTAKGTNAP TPIRVAGFTK RLMTSVLQLP EKSALAVLSL
LNRVVKMHAP KIAPLWNTEE RKGDGVFNPN AVDVEASNVF AATVWEGELL RVHYCPEIRD
ASRGIEKIIM SVK
//
