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Database: UniProt
Entry: A0A0J8RTP4_COCIT
LinkDB: A0A0J8RTP4_COCIT
Original site: A0A0J8RTP4_COCIT 
ID   A0A0J8RTP4_COCIT        Unreviewed;       526 AA.
AC   A0A0J8RTP4;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   28-JUN-2023, entry version 27.
DE   SubName: Full=Sir2 family histone deacetylase Hst4 {ECO:0000313|EMBL:KMU87349.1};
GN   ORFNames=CIHG_05141 {ECO:0000313|EMBL:KMU87349.1};
OS   Coccidioides immitis H538.4.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU87349.1, ECO:0000313|Proteomes:UP000054563};
RN   [1] {ECO:0000313|Proteomes:UP000054563}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SIMILARITY: Belongs to the sirtuin family. Class I subfamily.
CC       {ECO:0000256|ARBA:ARBA00006924}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00236}.
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DR   EMBL; DS016998; KMU87349.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J8RTP4; -.
DR   STRING; 396776.A0A0J8RTP4; -.
DR   VEuPathDB; FungiDB:CIHG_05141; -.
DR   Proteomes; UP000054563; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   PANTHER; PTHR47651; NAD-DEPENDENT HISTONE DEACETYLASE HST4; 1.
DR   PANTHER; PTHR47651:SF2; NAD-DEPENDENT HISTONE DEACETYLASE HST4; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          87..345
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..424
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  58005 MW;  FDBCB293444A912A CRC64;
     MEAYDLSDTS SNLSSPPMSP VPPSEFYPSP PTSQGLGIIP PIVSEPPMQP TPGPPTSTNK
     NTNNRRRRAV PPKPRISRHL DLGLVSHKDQ NDHLELLVSA LQNKRKIVVV AGAGISVSAG
     IPDFRSSHGL FKTLRKDHKL KASGKELFDA SVYLDSTMTS SFHDMVRLLS DMAATAKPSA
     FHHLLARLAK EDRLLRLYTQ NIDGIDTSLP PLTTEVPLNL KAPWPRTIQL HGVRAQREPG
     RWESYDLEFV LYNEHNPDEE AIGSVVRADL RTRPDALVVV GTSLKNPRGS AVSLKEMCRV
     VQGRKDGITM WINHDSAPVG RDFEHCWDLV VQGDCDEVAE LVGLKRWNDT GDETFAAFSA
     PEAESFKQGH GNNIAVVVPR SIAMAPKART HITPVEMPAN PATKYHPLKK PLDGKAEKPP
     RQRRTPHTNK SPPQRKLPSN FRVSKPSNQG EKNNVKNIFP DMQVSTIMHP ISPGAARNNG
     PMFPELVASS TSHPPATTPW NDTEIISPIG RIPADMQKIL ISRTNE
//
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