ID A0A0J8RTP4_COCIT Unreviewed; 526 AA.
AC A0A0J8RTP4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 28-JUN-2023, entry version 27.
DE SubName: Full=Sir2 family histone deacetylase Hst4 {ECO:0000313|EMBL:KMU87349.1};
GN ORFNames=CIHG_05141 {ECO:0000313|EMBL:KMU87349.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU87349.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SIMILARITY: Belongs to the sirtuin family. Class I subfamily.
CC {ECO:0000256|ARBA:ARBA00006924}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00236}.
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DR EMBL; DS016998; KMU87349.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8RTP4; -.
DR STRING; 396776.A0A0J8RTP4; -.
DR VEuPathDB; FungiDB:CIHG_05141; -.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR003000; Sirtuin.
DR InterPro; IPR026590; Ssirtuin_cat_dom.
DR PANTHER; PTHR47651; NAD-DEPENDENT HISTONE DEACETYLASE HST4; 1.
DR PANTHER; PTHR47651:SF2; NAD-DEPENDENT HISTONE DEACETYLASE HST4; 1.
DR Pfam; PF02146; SIR2; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR PROSITE; PS50305; SIRTUIN; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 87..345
FT /note="Deacetylase sirtuin-type"
FT /evidence="ECO:0000259|PROSITE:PS50305"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 58005 MW; FDBCB293444A912A CRC64;
MEAYDLSDTS SNLSSPPMSP VPPSEFYPSP PTSQGLGIIP PIVSEPPMQP TPGPPTSTNK
NTNNRRRRAV PPKPRISRHL DLGLVSHKDQ NDHLELLVSA LQNKRKIVVV AGAGISVSAG
IPDFRSSHGL FKTLRKDHKL KASGKELFDA SVYLDSTMTS SFHDMVRLLS DMAATAKPSA
FHHLLARLAK EDRLLRLYTQ NIDGIDTSLP PLTTEVPLNL KAPWPRTIQL HGVRAQREPG
RWESYDLEFV LYNEHNPDEE AIGSVVRADL RTRPDALVVV GTSLKNPRGS AVSLKEMCRV
VQGRKDGITM WINHDSAPVG RDFEHCWDLV VQGDCDEVAE LVGLKRWNDT GDETFAAFSA
PEAESFKQGH GNNIAVVVPR SIAMAPKART HITPVEMPAN PATKYHPLKK PLDGKAEKPP
RQRRTPHTNK SPPQRKLPSN FRVSKPSNQG EKNNVKNIFP DMQVSTIMHP ISPGAARNNG
PMFPELVASS TSHPPATTPW NDTEIISPIG RIPADMQKIL ISRTNE
//