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Database: UniProt
Entry: A0A0J8RWB7_COCIT
LinkDB: A0A0J8RWB7_COCIT
Original site: A0A0J8RWB7_COCIT 
ID   A0A0J8RWB7_COCIT        Unreviewed;       598 AA.
AC   A0A0J8RWB7;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   03-JUL-2019, entry version 17.
DE   SubName: Full=Tripeptidyl-peptidase 1 {ECO:0000313|EMBL:KMU88404.1};
GN   ORFNames=CIHG_06202 {ECO:0000313|EMBL:KMU88404.1};
OS   Coccidioides immitis H538.4.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Coccidioides.
OX   NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU88404.1, ECO:0000313|Proteomes:UP000054563};
RN   [1] {ECO:0000313|Proteomes:UP000054563}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
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DR   EMBL; DS017004; KMU88404.1; -; Genomic_DNA.
DR   EnsemblFungi; KMU88404; KMU88404; CIHG_06202.
DR   Proteomes; UP000054563; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054563};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    598       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5005308490.
FT   DOMAIN      212    598       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   ACT_SITE    288    288       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    292    292       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    503    503       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       545    545       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       546    546       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       578    578       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       580    580       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   598 AA;  65366 MW;  4CAE557B678EE181 CRC64;
     MSFNFIFQLL CFVLVAGITE AQSRPGGSWA LLERVNVPDG WIQGPIVDPS TMFSMKINLN
     TASQTEDLHQ KVMEIGTPGH ARYGLHLKQE EINTLMTPNE VVVNDVLKWI QDGGVGPEHV
     RTRANWIDIE LTIGAASKML NARFYEYKDE RTGLTKIRTT EYSAPKSVAQ HIFYIYPLVL
     FTRTAAQNKQ VARGFLQDLP SRGTVSGACP EGNTPKCLRG LYDLGNITAK AGSRNKIAVS
     GYLDQYAQYE DLAAFLQKFA PQAASANFSV SLVKGGQNIQ NSTRNSIEAN LDTQYAVALS
     YNMKVDFVSV KGRGLLKEDL DQPNQSQNQN EPYMDQLEYL MGLPDKDLPT VLTTSYGETE
     QSVPELYARA TCNEFAKLTA RGVSIIFSSG DTGVGSACTS NDGKNRTVFN PIFPASCPFV
     TAVGGTHSRN PERAVGFSAG GFSNYFKRPG WQDEAVTKYL SNLGTTWEGY YNPLGRGFPD
     VAAQAVKYPI YEKGSVITAA GTSASAPTIA AIIAHLNEVR LSQGKPVLGF LNPWIYSTGF
     KGFTDITHEG SIGCLGTSMY SKLPTRLVPY ASWNATKGWD PVTGFGTPDF KKLVKLLP
//
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