ID A0A0J8RXV2_COCIT Unreviewed; 785 AA.
AC A0A0J8RXV2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN ORFNames=CIHG_06825 {ECO:0000313|EMBL:KMU89024.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU89024.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS017009; KMU89024.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8RXV2; -.
DR STRING; 396776.A0A0J8RXV2; -.
DR VEuPathDB; FungiDB:CIHG_06825; -.
DR eggNOG; KOG0500; Eukaryota.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 2.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF16643; cNMPbd_u2; 1.
DR Pfam; PF00646; F-box; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 67..184
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 270..404
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 87160 MW; 6D54272844D4D4F2 CRC64;
MRRMTRGASA SPLAGKSATA GADPMSLIRT FNSETNPSRP LHPSPLAASQ IRGMPLDLID
RLRSFPLFQS TPESFLAEIG LHLRPQLNSP NDYILTEGDE AKAMYWLVRG AVAVTSRDGE
SVYAELKPGA FFGEIGILMD RPRTATIIAR TRCLLVVLTK EDFKNILPRF PEVERAIREE
AEERLQILEK KKTQAQPLPI RPERLAGERR GSKRLHEAFT GDMSLDDERR LDIISKKRKS
PSPGLAEGST SSALANGLVN VRMLLKELPL FSQLPPDILH FLGLNVQPRT FPPFTDIIRQ
DSQGREIYFI VRGEVEVINE RPDSRAARRG ADAESHRGVQ VKARLRQGQY FGEVVSLSLA
PRRTATVRSV TAVECLMISG EVLSEFWARC PRHIKEQVEH TAKKRLEAAS GGDVVMEDAP
QVSTFDSQEP VMPAARRQSM PLLTLTESDL DSFHKPSRLE DASVLRPSDP DPYLSVDLDN
MRARSRRGSL APIVPEDGTA ADQHTQASGL NRSPRSLSPS KQTNALPQSS LSPFKPIFRP
SFGNSRGIFN DDILITILQH LELHHLLRLR SVSRHWSNLI TKSPHLLHFL DLSIYNRKIT
DEVITDFICP FIGDRPRVVD INNCFHMTDE GFNALANACG ANLRALRMKS VWDVTAPAIL
DMANKAKELQ EIDLSNCRKV SDTLLARVIG WFVPGSQAPQ QPNGKGAHKG PMQTPIQTSA
GAVNSICLFA AHYQTPQLKS LLLAVRSLLI LISPFAAQQF LMLHSAPLAY TSCFSASYLF
EDASE
//
