ID   A0A0J8RXX3_COCIT        Unreviewed;       956 AA.
AC   A0A0J8RXX3;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Protein unc-45 homolog B {ECO:0000256|ARBA:ARBA00020768};
GN   ORFNames=CIHG_07703 {ECO:0000313|EMBL:KMU90020.1};
OS   Coccidioides immitis H538.4.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU90020.1, ECO:0000313|Proteomes:UP000054563};
RN   [1] {ECO:0000313|Proteomes:UP000054563}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, A band
CC       {ECO:0000256|ARBA:ARBA00004161}. Cytoplasm, myofibril, sarcomere, Z
CC       line {ECO:0000256|ARBA:ARBA00004216}.
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DR   EMBL; DS017017; KMU90020.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J8RXX3; -.
DR   STRING; 396776.A0A0J8RXX3; -.
DR   VEuPathDB; FungiDB:CIHG_07703; -.
DR   eggNOG; KOG0891; Eukaryota.
DR   Proteomes; UP000054563; Unassembled WGS sequence.
DR   GO; GO:0031672; C:A band; IEA:UniProtKB-SubCell.
DR   GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR024585; mTOR_dom.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR   PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR   Pfam; PF11865; DUF3385; 1.
DR   Pfam; PF02259; FAT; 1.
DR   SMART; SM01346; DUF3385; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:KMU90020.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW   Transferase {ECO:0000313|EMBL:KMU90020.1}.
FT   REPEAT          532..562
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          533..573
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          769..956
FT                   /note="FAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51189"
SQ   SEQUENCE   956 AA;  107496 MW;  2C2C3B563053A060 CRC64;
     MPSFVKESAP PPQEVTDSEI TLALLTLGSF DFSGHILNEF VRDVAIKYVD NDNSEIRKAS
     ALTCCQLFVH DPILNQTSSH SLQVVSQVID KLLSVGVGDP EPEIRCTVLQ SLDRKFDRHL
     AKPENVRCLF LAVNDEVFSV REAAISIIGR LSNVNPAYVF PPLRKLLVNL LTGLSFATTS
     RQKEESAQLI SLFVTNATKL VRSYVDPMVT TLLPKTTDLN AAVSATTIKA IGEIATIGGE
     GMKQYLAQIM PIILEALQDL SSPSKREAAL RTLGQLASNA GYVIEPYKEY PQLLAVLINI
     IKTEQAGSLR KETIKLIGTL GALDPYKYQQ ISQDTPDVHH INEIQAVSDV SLIMQGLTPS
     NEEYYPTVVI NTLLHNILSE SSLAQYHSAV IDAIVTIFKT LGLKCVPFLG QIIPAFISVI
     RDTPVSRLDT YFNQLAILVT IVRQHIRAYL PEIIVVIREY WDASYQVQAT ILSLVEAISK
     SLEGEFKKYL AGLIPLMLET IEKDSSPRRQ PSERVLHAFL VYGSSAEEYM HRIVPAIVRL
     FDKQQAPQNI RKSAIETLAK LSRQVNVSDF ASLMIHPLAR AIGSSDRTLR QSALDCVCTL
     IFQIGQDFTN YIQLINKQVL KNNQIHHHNY QILVSKLQKG EPLPQDLNPD EQYGSFGDDQ
     SFGEVGQRKI LVNQQHLKNA WDATQKSTRE DWQEWMRRFS VELLKESPSH ALRACASLAG
     IYQPLAKDLF NAAFVSCWTE LYHTYQEELV HSIDLALTAR NIPPEILQIL LNLAEFMEHD
     DKALPIDIRT LGNINNQLQQ FDAAIGILRK AQAYRDVELK ETWFVKLQRW EEALAAYKRR
     ELIDPDSFEV TMGKMRCLHA LGEWKMLSDL AQEKWNQATN DHRIAIAPLA AAAAWGRGQW
     ELMDSYIGVM KEQSPDRSFF GAILSLHRNQ FKEAAEYIEK ARNGLDTELS ALLDAR
//