ID A0A0J8RXZ4_COCIT Unreviewed; 516 AA.
AC A0A0J8RXZ4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Cytochrome P450 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CIHG_07258 {ECO:0000313|EMBL:KMU89451.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU89451.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR602403-1};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
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DR EMBL; DS017012; KMU89451.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8RXZ4; -.
DR STRING; 396776.A0A0J8RXZ4; -.
DR VEuPathDB; FungiDB:CIHG_07258; -.
DR eggNOG; KOG0684; Eukaryota.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11040; CYP7_CYP8-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR47582; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR PANTHER; PTHR47582:SF1; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00465; EP450IV.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|PIRSR:PIRSR602403-1};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR602403-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602403-1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..516
FT /note="Cytochrome P450"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005308373"
FT BINDING 441
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR602403-1"
SQ SEQUENCE 516 AA; 58020 MW; 4C5B0999A153914A CRC64;
MEQFYLHLLV LLVLSILLRF LIAPGHAPEE PPLVSSRIPF IGHLIGLARY GNRYYVRLSA
QSQLPAITIN IFRQKIYLIY SPGLLAAAQR HAKYISFEPF AALAIRRAAG IKGNGPIVSS
SSEKGRSSFD KQMKDAVHSV LLGEAMVGIT RASVAAIKKS VDDLRSTEVD LLTWCRHVLT
MATTDSIYGP MNPYRNREAE AAIWEFDSGL GKLTLNFAQR FIAREAYQAR EKLVKRLLEY
FEKCGYINAS SFVQRRLEVE RKAGATLEDI ARLETLMVLP LLSNSAPSTF WVLFDIFSRL
DLLEEIRKEI VQNALQFKPC DDSMGKPKQM CTLNMNNIRD KCPLLVATWQ ETLRLRANTA
SVRFVSKDTK LNDTYLLKAN SIVQTPANVL NVDPNIWGPD AHLYNPRRFL DTRASPGAGG
DRKRDRKWNG FMTFGASPWT CPGRHFATAQ ILALVSLLVM KFDISPVAGD WVSPRINHRS
MALAISIPAE GLMVNVVTRK EVKGIDWEFQ MMEGKA
//