ID   A0A0J8S7U8_COCIT        Unreviewed;       831 AA.
AC   A0A0J8S7U8;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=aminodeoxychorismate synthase {ECO:0000256|ARBA:ARBA00013139};
DE            EC=2.6.1.85 {ECO:0000256|ARBA:ARBA00013139};
GN   ORFNames=CIHG_10277 {ECO:0000313|EMBL:KMU92459.1};
OS   Coccidioides immitis H538.4.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU92459.1, ECO:0000313|Proteomes:UP000054563};
RN   [1] {ECO:0000313|Proteomes:UP000054563}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
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DR   EMBL; DS017081; KMU92459.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J8S7U8; -.
DR   STRING; 396776.A0A0J8S7U8; -.
DR   VEuPathDB; FungiDB:CIHG_10277; -.
DR   eggNOG; KOG1224; Eukaryota.
DR   Proteomes; UP000054563; Unassembled WGS sequence.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.880; -; 1.
DR   Gene3D; 3.60.120.10; Anthranilate synthase; 2.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I-like.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR015890; Chorismate_C.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR   PANTHER; PTHR11236:SF18; AMINODEOXYCHORISMATE SYNTHASE; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   SUPFAM; SSF56322; ADC synthase; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          326..402
FT                   /note="Anthranilate synthase component I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04715"
FT   DOMAIN          478..765
FT                   /note="Chorismate-utilising enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00425"
FT   REGION          559..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          630..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          806..831
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        630..652
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..692
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        808..831
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   831 AA;  93021 MW;  92F411DB4D058B86 CRC64;
     MSEKGEVSRP AKILYINAYD APSSDLISQL QRNLGVDVDV CDRVKTLGIK GCIPAFPLYD
     AVVVGPGDDS DVWEGSLAEL WDCEKVPILA VGVPFLDFCF EHHGGIEKFP RSLDGTHLDL
     VHCGENIFKG LGEFKVTPFY NYRAGIRHPT ERRVVDHQHE DNWYPSTRCS EIAPLAWCSI
     PSENQSALMA AHHLKNPIWA IYFRLEACKP TQLGSKLLKG WWRKVLIYNK HDRYKADGQD
     LPRIGKCTSS TKVSQRVIPL SQLTSEKICE IVGVPATESV VLKTLRYTIM SVRSCGAWVL
     EYSAKLGTLF VNRLSSHNPE SWKTTASGVT KAIRFIAHMR KASGGHPGIP FWGGFMGVFS
     YEMGIDILGI DVPSNDEGEA DTCFLWTERS IVIDHKQREV YIQSLRRSDD RQGEWLDLMM
     YRLSHFLCYP SLDHVFLNLS TTALGNIQRG MYILQINHTQ NELANLMVEG SKITFPGEET
     YKRKIRQCHD HIRAGDCDDL LLAAEANVTL PSCRYWETSS VRGWILLKQF MKFHPANFSA
     YMNIAHSKVI GGAQKSLLRG SRNEKRSGLH PENEPEKSPE EEPEKNPEKR LKDTADKEVE
     DLLTKANGLA KDKVFIDRLK GNLSKISKLR DAQIEKEAEH ENNSDMYRLP RDGEPEASSS
     VHQGGSSTAD NASSSGQHSI CDDPPSDSRT SDGMYSEILR KIENRPRGAF CGVAGYMDVG
     GGFEFLVLGH AAFTWSAPGT PEIWRVGAAA TISATSTAQQ GWDEVRGRLE ALLQIFRHRL
     DSEVDEGDPE REPVLKSLLK EHRGLFSQEQ CSETSSQASH YSQDDRSSAG K
//