ID A0A0J8TLW4_COCIT Unreviewed; 711 AA.
AC A0A0J8TLW4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 13-SEP-2023, entry version 36.
DE SubName: Full=Methylenetetrahydrofolate reductase 2 {ECO:0000313|EMBL:KMU74657.1};
GN ORFNames=CISG_00587 {ECO:0000313|EMBL:KMU74657.1};
OS Coccidioides immitis RMSCC 3703.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU74657.1, ECO:0000313|Proteomes:UP000054559};
RN [1] {ECO:0000313|Proteomes:UP000054559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS268119; KMU74657.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8TLW4; -.
DR STRING; 454286.A0A0J8TLW4; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000054559; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF1; METHYLENETETRAHYDROFOLATE REDUCTASE 1; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054559}.
SQ SEQUENCE 711 AA; 78364 MW; 1B8C197523F2727E CRC64;
MEKISNKIAA LPEDANYFSL EFFPPKTQMG SANLQARLER MSQALRPLFV TVTWGAGGTT
ATKSLELAEI CQRQLGLTTC LHLTCTNMNR TLIDSALDEA KALGIRNILA LRGDPPRSDE
YNLDGEDDSN KEFTYAVDLV RYIRKKHSDY FCIGVAAYPE GHSDESHPGV QDPVRDLPYL
VEKTKAGADF IMTQLTYDLE AYKRFESMLR NHESGVFKTI PIIPGLMPIQ SYPRLTRITK
LSHVRVPPEM LSRIEACKKD DEAVKKVGVD ILSELVEGIK TIPGTGPRGL HFYTLNLEKS
VSFILERCNL IPPSSEASSD TDSDSVFASG NLQNGLGTAA GKPPLISRRR ASSLNSQPHN
RVIVDRADIS SQSSITHEAS AQGAGMPALN PPHRNTALQI SEGMGALGRE ATWDDFPNGR
WGDARSPAFG EIDGYGPSLH VTANVARRLW GYPTTREDIN NIFRQHVSGG LHAVPWSEGG
AAEETGGLSP ETITIRPYLL SLIEKRGWWT IASQPAVSGV RSDHPIFGWG PPGEGFVFQK
AFVEFFCSKD DYRSHLKPLL QRYGHDEFAW FATNAAGDFE SSTSSSIPVP TGPVDAVFDD
MDSFPSSNSG GVNAVTWGVF RGKEIITPTI IEEVSFRAWG EEAFRIWDEW RRIFPRGSPT
EKLLNRVKED TWLVCVIGQR FGAGGDPGKD AMEEGKILWK VLAGENVSLQ S
//
