ID A0A0J8U101_COCIT Unreviewed; 1963 AA.
AC A0A0J8U101;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Linear gramicidin synthetase subunit D {ECO:0000313|EMBL:KMU79997.1};
GN ORFNames=CISG_08157 {ECO:0000313|EMBL:KMU79997.1};
OS Coccidioides immitis RMSCC 3703.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU79997.1, ECO:0000313|Proteomes:UP000054559};
RN [1] {ECO:0000313|Proteomes:UP000054559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; DS268181; KMU79997.1; -; Genomic_DNA.
DR STRING; 454286.A0A0J8U101; -.
DR Proteomes; UP000054559; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR CDD; cd19542; CT_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054559}.
FT DOMAIN 311..388
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 867..943
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1963 AA; 218865 MW; 75FBEAA3F7625538 CRC64;
MTLCSATNDI IFRDIEGAIR TLEVTHLSLT PSVAALVRSR NVPKVQFLVT AGEALTPEVA
KEWADVGVYQ GYGPCETTNI CTVKPRVRTT DVLSNIGKPF KNTSAFVLSQ GNTFSPVPRG
AVGELCFGGK QVALGYLNMP DVTQEKFVEH PEYGKVYRSG DYGRMLPDGS LAFVGRRDDL
VKLRGQRIEL GEVNSAILQS RVVKSCTTLI CGDKSSGSQL LVSFWVPVAD SSPYIKVDPK
RSSILTKELY DTISKILPMY MIPSFILPIE TIPVTVNGKV DKRLLADMYS NAAPDYLDLF
SNNAEISDNS EELSETESRI VQLVAAVTKT PATDIGRHSS FYRLGMDSIL AVSLSRQLKL
SGFGQVDVSV IMKNDTVSRL AAAVDRVSDT ATTKQEILPN FEVLFSPGFI EKARHDVEMA
QKKIRKILPC TPLQEAMLSQ MVSSDQKSYF NHLIFEVRKD MSRLKFAWEA MVARHDILRT
WFQSTNDAQH AFAQIVLDTV DLPWSFMECS SANVESIIER RKVSILSASG VAVPYAFIEL
HNITTGKSQL HLLIHHALYD GEAMGQLLQE VEQVVLDMAL PPVVPFDHYI EHMIKTDVEA
ATQFWNSHLT GFSPTYLVSP VPNASATKHK EFHSVSIDLD IPLTQVAESC KNASVTLLSL
LQAAWAKLLF FYSETSDICF GDVASCRTLP VNGPERIVGP CFNTLPLRVK LDSNTVNSDL
MLQLRKFKAD VLPYQLTSLR RLQSQFSPSG SRLFDTLLLL QKEPQRLNEE IWTLVDEHGD
MDFPFICEIV PNSEKDVLRV CLYCDGSKTS LDSVRQMLGG YVESIHHTLQ YPSARATDTS
VVKSGIPPFI NISRPIVEKE TMNDDLREWS NKALEVRELV SELAKVERKH IKLNTTIYKL
GLDSINAIQI AANLRAKGYE ISAGDILEAP TISQIASRLE KLTINGESSI MEAFDFNPFQ
ARHWVSVCTE IGQLEAKLQS VRPCTTVQTG GNLYFNHMCL QSTRPLDIDA LKRAWEAAVD
RNEMLRTGFC QVKDEVSPFA MITYKPGTLD LPWHDYVSEN GQLLHHEEPT GIEILNRLHY
PAWFLTVESL PTHTTIRFSA LHALYDAHSL NLILSEVARQ YNGGILFDPV PISPVLGSIL
TKGAEKDEIT EKIWEELCKG WPVTKFPDLN PIRTDRREMC TVSKTSSESL STIYTGCTKA
EVTLQAAGQA AWARLLASYV GEIDIGYGVV LSGRDMSAAA QDVVFPCLTT VPSRYRVEGS
NRELVQAVMK LNAHLIKGQH VPLSKLQRMT GSDTALFDTL FVHQKFMSST NDEQFWTVTK
EIATTDYPVS IELIPKGDKL EFCVTFRNDI LPVDQAHILI DQLEWLLFDT IFSPESNCAH
FMGADRRITC VVPRKDAYIE APVDLLHQFV EVNASECPSK IALEFASRSS EVEDKLIVRS
WTYKEFNDQG NKYANLLLQL GASKSKLIGI CFDKCPEAYF AILAILKVGS AYVALDPGAP
IARKKFIMED SGSNFLLCTS DKKEELMGID GVKVLALDEA GLLNGLSSSS PILEHPISGD
DTCYCLYTSG STGTPKGCEI THSNAIQAML SFQRLFAGHW DDSSRWLQFA SFHFDVSVLE
QYWSWSVGIC VTSCPRDILF EDLAGVIRQL EITHIDLTPS LARLLQPDEV PSLCRGVFIT
GGEALKQEIL DTWGEKQVIY NGYGPTEVTI GCTMLPRVTQ WDKPSNIGPQ FDNVGSFVFK
PGTNIPVLRG GIGELCVSGP LVGRGYLNRP ELTEERFKYL DEWGERVYRT GDLVRMLHDE
SFCFLGRMDD QVKLRGQRLE IDEINHVIKS ASAEIGEVVT MVLKHLSAGK EQLVSFITRG
ELSEKEAILG FDTGDHVHET LNDIRRCCSL QLPGYMVPTH VIPLTRFPLS PNNKIENKKL
KEIYANLTLE QMQKLSPQNE ENTTNASRET KKIISIVSPV GRL
//
