ID A0A0J8UKE6_COCIT Unreviewed; 759 AA.
AC A0A0J8UKE6;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=AdoMet-dependent rRNA methyltransferase spb1 {ECO:0000313|EMBL:KMU87963.1};
GN ORFNames=CIHG_05730 {ECO:0000313|EMBL:KMU87963.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU87963.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; DS017001; KMU87963.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8UKE6; -.
DR STRING; 396776.A0A0J8UKE6; -.
DR VEuPathDB; FungiDB:CIHG_05730; -.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR012920; rRNA_MeTfrase_SPB1-like_C.
DR InterPro; IPR024576; rRNA_MeTfrase_Spb1_DUF3381.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10920:SF13; PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3; 1.
DR PANTHER; PTHR10920; RIBOSOMAL RNA METHYLTRANSFERASE; 1.
DR Pfam; PF11861; DUF3381; 1.
DR Pfam; PF01728; FtsJ; 1.
DR Pfam; PF07780; Spb1_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KMU87963.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KMU87963.1}.
FT DOMAIN 24..126
FT /note="Ribosomal RNA methyltransferase FtsJ"
FT /evidence="ECO:0000259|Pfam:PF01728"
FT DOMAIN 179..334
FT /note="DUF3381"
FT /evidence="ECO:0000259|Pfam:PF11861"
FT DOMAIN 556..755
FT /note="Ribosomal RNA methyltransferase SPB1-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF07780"
FT REGION 157..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..406
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..505
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 85934 MW; C757282789D17F5E CRC64;
MAIQKKHGKG RLDKWYKLAK EKGYRARAAF KLIQLNKKYG FLEKSKVLLD LCAAPGSWCQ
VAAECMPTES LIVGVDLAPI KPIPRVITFQ SDITTDKCRA TIRQHLKTWK ADTVLHDGAP
NVGTAWTCFF RNFSSYAADL HLRNPIDSIF PASPAIFSAD TPTSPPPKHE AKGIQPRRRK
KRKTEGYEER DSTQHKEIPV TEFINTTDPI AMLGTYNTLS FHQSPSGDLA LATLERLPET
TDEIRNCCED LKVLGKKEFR TLLRWRLKVR EQFGLAVKKG AKKAEESEEV AEIEPMDEEL
AIQEEMQRLQ EHESSRKKKE RRRENERKQK EIVRLQMHMI TPTDIGMEQS GPMGEGAMFS
IKPITREGAT RNITSGKMVD VQSEEDEESS ATSDVASDDE EDRLERELDA MYEKYQEDRE
ERDSKLRAKK ARKGLETEEW EGFSDSDKES DRLTDDDEDA PQAQPGILRN GQANGLSNKA
ALFFDQDLFQ GLGNEDDEED EEGEEAERKQ NPSEQDEESD DDNDPEDYET TDNESKMSVD
SLPATKKQSG RSSKPNAEGF EEQKDDPRTK EGKLDIDIIT AEAMALAQQM ATGEKTSADV
VDDGFNKYAF RDIDGLPEWF LDDENKHSKP LRPITAAAAA AIREKMRAIN ARPIKKVREA
KGRKKFKEAQ RLEKLKKKSA LLAEDEGVSE RDKAQTIARM MARATKKKPK QNVKLVVAKG
GNRGISGRPR GVKGKYKIVD ARLKKDVRAQ KRLAKKRNK
//
