ID A0A0J8Y0T6_9GAMM Unreviewed; 537 AA.
AC A0A0J8Y0T6;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=malate synthase {ECO:0000256|ARBA:ARBA00012636};
DE EC=2.3.3.9 {ECO:0000256|ARBA:ARBA00012636};
GN ORFNames=C9I94_12410 {ECO:0000313|EMBL:PSW24138.1};
OS Photobacterium swingsii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Photobacterium.
OX NCBI_TaxID=680026 {ECO:0000313|EMBL:PSW24138.1, ECO:0000313|Proteomes:UP000240481};
RN [1] {ECO:0000313|EMBL:PSW24138.1, ECO:0000313|Proteomes:UP000240481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24669 {ECO:0000313|EMBL:PSW24138.1,
RC ECO:0000313|Proteomes:UP000240481};
RA Butler K.;
RT "Whole genome sequencing of Histamine producing bacteria.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+);
CC Xref=Rhea:RHEA:18181, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15589, ChEBI:CHEBI:36655, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001699};
CC -!- SIMILARITY: Belongs to the malate synthase family.
CC {ECO:0000256|ARBA:ARBA00006394}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSW24138.1}.
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DR EMBL; PYLZ01000006; PSW24138.1; -; Genomic_DNA.
DR RefSeq; WP_048898087.1; NZ_PYLZ01000006.1.
DR AlphaFoldDB; A0A0J8Y0T6; -.
DR STRING; 680026.AB733_06865; -.
DR OrthoDB; 9768429at2; -.
DR Proteomes; UP000240481; Unassembled WGS sequence.
DR GO; GO:0004474; F:malate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR CDD; cd00727; malate_synt_A; 1.
DR Gene3D; 3.20.20.360; Malate synthase, domain 3; 1.
DR Gene3D; 1.20.1220.12; Malate synthase, domain III; 1.
DR InterPro; IPR044856; Malate_synth_C_sf.
DR InterPro; IPR011076; Malate_synth_sf.
DR InterPro; IPR006252; Malate_synthA.
DR InterPro; IPR001465; Malate_synthase_TIM.
DR InterPro; IPR048355; MS_C.
DR InterPro; IPR048356; MS_N.
DR InterPro; IPR046363; MS_N_TIM-barrel_dom.
DR NCBIfam; TIGR01344; malate_syn_A; 1.
DR PANTHER; PTHR42902; MALATE SYNTHASE; 1.
DR PANTHER; PTHR42902:SF1; MALATE SYNTHASE 1-RELATED; 1.
DR Pfam; PF20659; MS_C; 1.
DR Pfam; PF20656; MS_N; 1.
DR Pfam; PF01274; MS_TIM-barrel; 1.
DR PIRSF; PIRSF001363; Malate_synth; 1.
DR SUPFAM; SSF51645; Malate synthase G; 1.
PE 3: Inferred from homology;
KW Glyoxylate bypass {ECO:0000256|ARBA:ARBA00022435};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT DOMAIN 21..74
FT /note="Malate synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF20656"
FT DOMAIN 166..411
FT /note="Malate synthase TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF01274"
FT DOMAIN 416..535
FT /note="Malate synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20659"
FT ACT_SITE 170
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001363-1"
FT ACT_SITE 451
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001363-1"
SQ SEQUENCE 537 AA; 60332 MW; 4DAEAB33EE261627 CRC64;
MSTDNTLSSH HVKLSLQKAL SPDQQEIVSD EALAFLERLV ERFAEQVPSL LNARDERQQR
IDAGELPDFL AETANIREGS WSIQNIPADL QDRRVEITGP VERKMVINAL NANVKVFMAD
FEDSFSPAWD EVVAGQRNLR DAVNGTISYT NPTNGKQYQL NDDPAVLICR VRGLHLPEKH
LLWQGVPIPG ALFDFALYFF HNYKQLLAKG SGPYFYLPKL QAHQEAAWWS DVFSFAEDEM
GLSRGTIKAT VLIETLPAVF EMDEILYSLQ EHIVGLNCGR WDYIFSYIKT LRNYPDRILP
DRQVVTMEKP FLNAYSRLLV RTCHRRGAFA MGGMAAFIPS KDAEKNAWVL NKIQTDKSLE
ANNGHDGTWV AHPGLADTAC AVFNETLGNR HNQLDVSRSE DAPITAAELL APCDGERTEE
GMRHNIRVAV QYIEAWITGN GCVPIYGLME DAATAEISRA SIWQWIKHGK DLSNGKVVTA
ALFEEMLAEE MQVLEQELGS DIFAAGQYQE AAELMARLTT SDELMNFLTV PGYEYLP
//
