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Database: UniProt
Entry: A0A0J8YI15_9GAMM
LinkDB: A0A0J8YI15_9GAMM
Original site: A0A0J8YI15_9GAMM 
ID   A0A0J8YI15_9GAMM        Unreviewed;       961 AA.
AC   A0A0J8YI15;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Protease 3 {ECO:0000256|ARBA:ARBA00017565};
DE            EC=3.4.24.55 {ECO:0000256|ARBA:ARBA00012449};
DE   AltName: Full=Pitrilysin {ECO:0000256|ARBA:ARBA00033450};
DE   AltName: Full=Protease III {ECO:0000256|ARBA:ARBA00031184};
DE   AltName: Full=Protease pi {ECO:0000256|ARBA:ARBA00029597};
GN   ORFNames=AI28_11940 {ECO:0000313|EMBL:KMV69045.1};
OS   bacteria symbiont BFo1 of Frankliniella occidentalis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae.
OX   NCBI_TaxID=1628855 {ECO:0000313|EMBL:KMV69045.1, ECO:0000313|Proteomes:UP000037152};
RN   [1] {ECO:0000313|EMBL:KMV69045.1, ECO:0000313|Proteomes:UP000037152}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BFo1 {ECO:0000313|EMBL:KMV69045.1,
RC   ECO:0000313|Proteomes:UP000037152};
RA   Facey P.D., Hitchings M.D., Hegarty M.J., Pachebat J.A., Morgan L.V.,
RA   Hoeppner J.E., Whitten M.A., Dyson P.J., Del Sol R.;
RT   "The draft genomes, genome evolution and classification of BFo1 and BFo2
RT   two insect symbionts isolated from Western Flower Thrips (Frankliniella
RT   occidentalis [Pergande]).";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endopeptidase that degrades small peptides of less than 7
CC       kDa, such as glucagon and insulin. {ECO:0000256|ARBA:ARBA00002184}.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KMV69045.1}.
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DR   EMBL; JMSO01000185; KMV69045.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J8YI15; -.
DR   STRING; 1628855.WB66_17275; -.
DR   PATRIC; fig|1628855.3.peg.2410; -.
DR   Proteomes; UP000037152; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:KMV69045.1};
KW   Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..961
FT                   /note="Protease 3"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005312291"
FT   DOMAIN          55..192
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          215..393
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          400..671
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          682..857
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   961 AA;  107704 MW;  4EF007FA06F44E3D CRC64;
     MRRYAVWLAC FVSVTLFAPL VQAQDGWQPI TETIRKSEKD PRQYQAIKLD NGMTVLLVSD
     AQATKSLAAL TLPVGSLENP TDQLGLAHYL EHMVLMGSKR YPQPDNLAEF LKKHGGSHNA
     STASYRTAFY LEVENDALQP AVDRLADAIA EPLLDPVNAD RERHAVNAEL TMARSRDGLR
     MAQVGAETLN PEHPSSRFSG GNLETLRDKP GSKLHDALTA FYHRYYSANL MKAVIYGNQP
     LPELQKIAAA TFGRVANHHA TVPDISVPVV TDKQKGIIIH YVPAQPRKQL KIEFRIDNNS
     DKFRSKTDTL IGYLIGNRSK NTLSDWLQNQ GLADSISAGA DPVIDRNGGV FSIAISLTDQ
     GQAKRDEVIA AVFSYLNQLR TEGIDKRYFD EVAHVLDLDF RYPSITRDMD YIEWLVDTML
     RVPVADTLVA PYIADDYDAQ AIGARLDGMT PENARIWFIS PKEPHNKTAY FVDAPYQVDK
     ISAQRFKDWQ VESDKIKLSL PVLNPYIPDD FSLIKADKAY ARPQELMNQQ GLRVFYMPSQ
     YYADEPKANI TLALRNKAAM STAQNQVMFA LNDYLAGVAL DELSSQASVG GISFSTSEDD
     GVTFSATGFT QRLPKLMSQL LKGYTSFTPT QAQLEQAKSW YLERLDAADK GKAFELAIQP
     AQLLSQLPYT QRSERRKLVA TISLQQLMDY RKMLLEQSAP ELMVVGNMTP DAVRSLATEV
     KTQLNCEGHE WWHSEHVTIT KPTLANLQEA GSSTDSALAA VYVPVGFEEY QSMASSAMLS
     QIIQPWFYNQ LRTEEQLGYA VFAFQMPVGR QWGIGFLLQS NVKQPAFLLS RFKAFYPTAE
     KRLREMSKAD FAQYQAAMIN ELKQRPQTLD EEAGRFSKDF DRENYKFDTR EKVIAQIQAL
     TPQSVADFFH QAVMAPTGLA LLSQISGSHH GKADYAKEKG WTTWKDLSTL QQSLPVSQDT
     P
//
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