ID A0A0J9UQD6_FUSO4 Unreviewed; 1485 AA.
AC A0A0J9UQD6;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN ORFNames=FOXG_04757 {ECO:0000313|EMBL:KNB01535.1};
OS Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935
OS / NRRL 34936) (Fusarium vascular wilt of tomato).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=426428 {ECO:0000313|EMBL:KNB01535.1, ECO:0000313|Proteomes:UP000009097};
RN [1] {ECO:0000313|EMBL:KNB01535.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4287 {ECO:0000313|EMBL:KNB01535.1};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Ma L.-J., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Young S., LaButti K., DeCaprio D.,
RA Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C.,
RA Larson L., White J., O'Leary S., Kodira C., Zeng Q., Yandava C.,
RA Alvarado L., Kistler C., Shim W.-B., Kang S., Woloshuk C.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KNB01535.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4287 {ECO:0000313|EMBL:KNB01535.1};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
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DR EMBL; DS231700; KNB01535.1; -; Genomic_DNA.
DR RefSeq; XP_018239580.1; XM_018382793.1.
DR GeneID; 28946776; -.
DR KEGG; fox:FOXG_04757; -.
DR VEuPathDB; FungiDB:FOXG_04757; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000009097; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF16073; SAT; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009097}.
FT DOMAIN 346..777
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 1485 AA; 162231 MW; A82796D1EE23F6AD CRC64;
MASSTDVYVF GDQSTPVLDK LQALLRVKDN ALLTYFLGEA FLAVRHEIVS LSSIERKSIP
EAESLSLLLE GVRRSEPHAA LDSAFVCIYE IGYYIDIAAA AVSCAKDVFE ISKLGVEAAT
VAFRLGMHVR RRAENLGYST PSSWSMILSS NQEELVSEAL QEFSKDKNLT SSTRPYVSAV
GPGFTTVSGP PSILESLKAL DTFSGKRLYP APIYGPYHSA LAYSESSLEH AIASILEDTE
FLENKMLIPI ISCASGSRLD QLSFGSLLKD VLSSALSQQI RMDLVTDALL ETISGSDATL
IPVNAQTTVC SLADWLAKRG ATTRIGPTLE SLVKDQAEPQ VAPGDENKIA IIGFSGRFPE
ADNLDKFWDL LIRGLDVHKP VPEERFARDH YDPTGQRKNT SQVQYGCWLK SAGYFDTQFF
HMSPKEAMQT DPAQRLALLT AYEALEMAGV VPDRTPSTQR NRVGVYYGTT SNDWGEVNSS
QDVDTYYIPG ANRAFIPGRV NYFFKFTGPS IAVDTACSSS LAAINLAITS LKNRDCDTAI
AGGTNVMTNP DNFAGLDRGH FLSRTGNCKA FDDGADGYCR ADGIGTLILK RLPDAIADSD
PIFGVILGAH TNHSAESVSI TRPLADAQEY LFKKLLNETG IHPHDVSYVE MHGTGTQAGD
AVEMRSVLNS FAFDHSRPRD KSLYLGSVKA NVGHAESASG VLAIIKVLLM MQKNTIPPHC
GIKTKINQGF PKDLDHRGVR IAQKESVDWS RPEGGKRRVL VNNFSAAGGN TSLLLEDGPA
VHPARQHQDG DPRTEHVVAV SARSTKALEE NMKALEAFIA NSWAPEGELL SQLSYTTTAR
RVHHSRRVAF VTNGLDDLRK SLLNAAAAAG QVKGIPAVSP KVGFIFTGQG AQETAMANGY
YKSFSSFRSD IHQLDSIATL QGFPSVLPLI HGTTPVEDLS AVVVQLGTCI IQIALARFWI
SLGITPQYVI GHSLGEYAAL QIAGVLSVND AIFLCGHRAA LLDKKCTAYT HGMVAVKAAA
DDLRQRISSD LKVEIACVNG TEDTVLSGPN ADIESLCGKL TQAGYKLHKL EIPFAFHSSQ
VDPILDDLEE LASQVEFHEP KLPIVSPLLR TLLTGDTLGP QYIRRHCRET VDFLGAIKMA
EAQGIMDRTG MCIEIGAHPI LTRMVKSIIG QEFRCLASLR RKEDHFKTLA DSLCALHLAG
LSINWDEYHR DFASSRNVLQ LPKYSWQLAN YWMQYKYSWC LTKGDAPVEN GLVGAVVQTR
ALRLSDSVHN VIEQVHGDKR SSITVESDMH DASLLTIAQN HRVNGLTMAP STLFADIAFT
LAKHLIQTHG LDAQTNLPSI NNMAVEKALI VGETGPQLFH ASLDMDWTSM HGSVRIFSVN
ASGKQTTLHA VCDVAVENPS SHRESWQSHA YLIQRGITQL VKGAGDGTAH MMRRGLLYKI
FSNSVQNWQG LHAIRQGHFC TQPVLLRQFG PHHRLHHELQ RQLGP
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