ID A0A0J9XAP4_GEOCN Unreviewed; 472 AA.
AC A0A0J9XAP4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Pre-rRNA-processing protein IPI3 {ECO:0000256|ARBA:ARBA00026229, ECO:0000256|RuleBase:RU369067};
GN ORFNames=BN980_GECA06s01451g {ECO:0000313|EMBL:CDO53899.1};
OS Geotrichum candidum (Oospora lactis) (Dipodascus geotrichum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Geotrichum.
OX NCBI_TaxID=1173061 {ECO:0000313|EMBL:CDO53899.1, ECO:0000313|Proteomes:UP000242525};
RN [1] {ECO:0000313|EMBL:CDO53899.1, ECO:0000313|Proteomes:UP000242525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 918 {ECO:0000313|EMBL:CDO53899.1,
RC ECO:0000313|Proteomes:UP000242525};
RA Casaregola S.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC sequences from 35S pre-rRNA. {ECO:0000256|ARBA:ARBA00002355,
CC ECO:0000256|RuleBase:RU369067}.
CC -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC particles. {ECO:0000256|RuleBase:RU369067}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369067}.
CC -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family.
CC {ECO:0000256|ARBA:ARBA00010143, ECO:0000256|RuleBase:RU369067}.
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DR EMBL; CCBN010000006; CDO53899.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J9XAP4; -.
DR STRING; 1173061.A0A0J9XAP4; -.
DR OrthoDB; 21962at2759; -.
DR Proteomes; UP000242525; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0097344; C:Rix1 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR045227; WDR18/Ipi3/RID3.
DR PANTHER; PTHR18763:SF0; WD REPEAT-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR18763; WD-REPEAT PROTEIN 18; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|RuleBase:RU369067};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|RuleBase:RU369067};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 186..227
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 288..349
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 296..337
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT COILED 438..472
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 472 AA; 52302 MW; 32D7360E04505CFC CRC64;
MEELVLYGTL AAAGASGPRN PQKMKSGQQN HNNSSIVVCD LHSGTPYQTF KNVSLPRGST
LQAVHATSDR VFSVQHNSSV LLVYHWGRDS AVQTIVLPEK LAVVKVSPSG NWLIGGAQTG
RIYIWEVMSG NLVAVREKHY QEVTVIEFGR DDDSFVFTGS KDSTVLGWRL YDLVNSGECQ
PVYSWNKVHS LEITGVRLGY GLRNVYTSSL DNTLRCWDLE RNELVSTYIL PEKIKAIAMD
PSERAVYAGL INGDIIIVNR YKVNPTTGMV EGPKGNNEKV TLTYQDNSDI LLTRPDSDTK
ASVTCLDISF DGTVLAAGYS DGQAYTWDIT TKQVLRKLAP QKEAVSSIQI VSRSRKVIPG
GIKLTGNNSN MLAKKKNDTS AEIFKLPIFK RILDEKEIEN HNVWVKLADA PKQEVDDLAQ
VKVKMAKFLH EPRFIASAKV SKSNVAALTG RVKELEAQLQ RAKDLKQAKE MM
//
