ID   A0A0J9XDA9_GEOCN        Unreviewed;      1002 AA.
AC   A0A0J9XDA9;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=DUF221-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN980_GECA11s02364g {ECO:0000313|EMBL:CDO55511.1};
OS   Geotrichum candidum (Oospora lactis) (Dipodascus geotrichum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Geotrichum.
OX   NCBI_TaxID=1173061 {ECO:0000313|EMBL:CDO55511.1, ECO:0000313|Proteomes:UP000242525};
RN   [1] {ECO:0000313|EMBL:CDO55511.1, ECO:0000313|Proteomes:UP000242525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 918 {ECO:0000313|EMBL:CDO55511.1,
RC   ECO:0000313|Proteomes:UP000242525};
RA   Casaregola S.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC       {ECO:0000256|ARBA:ARBA00007779}.
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DR   EMBL; CCBN010000011; CDO55511.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J9XDA9; -.
DR   STRING; 1173061.A0A0J9XDA9; -.
DR   OrthoDB; 1330110at2759; -.
DR   Proteomes; UP000242525; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR   InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR   InterPro; IPR032880; Csc1/OSCA1-like_N.
DR   PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR   PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF02714; RSN1_7TM; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        30..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        116..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        164..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        430..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        480..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        541..567
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        588..607
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        650..670
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        676..695
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          30..184
FT                   /note="CSC1/OSCA1-like N-terminal transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF13967"
FT   DOMAIN          209..373
FT                   /note="CSC1/OSCA1-like cytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF14703"
FT   DOMAIN          385..669
FT                   /note="CSC1/OSCA1-like 7TM region"
FT                   /evidence="ECO:0000259|Pfam:PF02714"
FT   REGION          926..1002
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        926..994
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1002 AA;  115931 MW;  DE3F54AF0EBA9DDB CRC64;
     MSTETSDAGQ QLLQFLQESF KSAQYTAKSV LAGLVFSLGG SIILFIIFCL IRPRNNIVYA
     PKNKYPESQG KKPEPLGKHP FSWMLSVFRM SDDRLVDFIG IDAVLYIKFM TMLRNIFLVL
     AVLGCLVMIP INVTYNAKSP LAPSVSKSDA FILMTPTLIY GTPLYAHIVL AYIFDFYILF
     MLWRTFNQVI QMRRNKFKTE EYQNALFMRT LMLTEVPKKY HSEDGLISLM GKLKVSRPIQ
     NATIGRDVKE LTKLIQRHTK AVYKLESVLA KYLKNPDKLP AKRPVCRPFK FDTTAHKGKI
     DAIDYLCNII EQLEKEIGMV RESIDTHKTL PYGFVSYESV EDCHVVAKST QRKRKGKLNA
     TLAPRPSDII WDNIVLTRLQ RANKQHWGNF LFLALMILWI APNAFMGVFL SNLNRIGALW
     PPFTGFMYNY PIIFSILQGV LSPVVTSLIF LILPAIMRKM SQWQGKVTKH EREMDTTKKL
     YAFFVFNNLF IFTVFSVIWN IISKTIQLIK NGHDLTFDKV MDELNIAQQL STSILGASSF
     WVMYILRVNF GAVLDLLQLF SLLWRGFQRH FLSPTPRELM LWTAPQHFNF AAYYNWLLFY
     ATIALSFSMV QPLVLPVISF YFVLDVIFKK YSLMYIFVTK AESDGLYWPF LHNAMLFATG
     FGNLALFAVI WVQGGWIKAV CLGPLPVIII IYKIVSVRVH NDRFYYFIPT EQENAEMESL
     RTRTNLSDIS SGALERRYRN PTITGKLLMP MVHSKAQHIL PQICNINNYY NEDAEMETAF
     KNLSDEYEGY HMNDLGHDGF ENNDLLRRFD IVDENDLTFE KYQEIERERL KTPFNPLLQQ
     QQPVNLYQHN YNSQQSLMGA QESGEYNAHY DMGSSNQGYS HYNDAASIRS QTPLNSVPSS
     TTVYNNTPYN QQVEYQETAY HSPYHQQPHY QNSYQQQNQN SYPQQNQHYN PYEQQQQQQP
     QSRSVSDSVS YTSYNDGLGV FNPNASNLTL ESDDQQRLLN RH
//