ID A0A0J9XDG4_GEOCN Unreviewed; 3152 AA.
AC A0A0J9XDG4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Vacuolar protein sorting-associated protein {ECO:0000256|PIRNR:PIRNR037235};
GN ORFNames=BN980_GECA10s03101g {ECO:0000313|EMBL:CDO55305.1};
OS Geotrichum candidum (Oospora lactis) (Dipodascus geotrichum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Geotrichum.
OX NCBI_TaxID=1173061 {ECO:0000313|EMBL:CDO55305.1, ECO:0000313|Proteomes:UP000242525};
RN [1] {ECO:0000313|EMBL:CDO55305.1, ECO:0000313|Proteomes:UP000242525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 918 {ECO:0000313|EMBL:CDO55305.1,
RC ECO:0000313|Proteomes:UP000242525};
RA Casaregola S.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. May play a role in mitochondrial lipid
CC homeostasis. {ECO:0000256|PIRNR:PIRNR037235}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545, ECO:0000256|PIRNR:PIRNR037235}.
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DR EMBL; CCBN010000010; CDO55305.1; -; Genomic_DNA.
DR STRING; 1173061.A0A0J9XDG4; -.
DR OrthoDB; 199953at2759; -.
DR Proteomes; UP000242525; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-UniRule.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IEA:UniProtKB-UniRule.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR017148; VPS13_fungi.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR PIRSF; PIRSF037235; VPS13_fungi; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037235};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|PIRNR:PIRNR037235};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037235}.
FT DOMAIN 2..115
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 140..368
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 593..829
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1925..2496
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2749..2923
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3021..3126
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 435..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1531..1548
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3152 AA; 357333 MW; 53A5CEEB368C9A44 CRC64;
MLESLVASLL NRFLGSYVKN FDPKQLNIGI WGGDVKLRNL SLKREALDQL KLPIDVVEGH
LGQLVLQIPW SNLKNKPVKV LIEDVFLLAV PKLDQDYDDD EQQRRNQAVK LSRLDDLELA
DKMSTSINLS PEEIRKNQSF TDSLVTKIID NLQITIKNIH IRYEDHTSVP NHSFSLGISL
EELSAVSTNS EWDPIFIQDT TNITHKLTTL SSLSIYWNTD SKLIKEDELP EILRFMSLVP
GLKENITDSF QYILRPVSGL GRITINKTAV GGPKTKAQLM FDELGFVFDS DQYRDVLWVA
EIFRIYNRTK EFQKFRPKTP VMKNPKAWLK YAANVVLAEV KQKRREWTWD YILERREDKL
RYIHLYKKKT ISPPLSAEET EEFNQLEIKY SFEDLRFYRS LAKSELKKEK AQIKAAQVEK
PAASGWSSWL WGSSAEPDKA DETASDTENP DSVTITDEQR QELYDAIEWD EKQVITDSID
VPRDTVTLEV EATLKTGSFK LRRNPHNNPE DIVQILFTGL SSSFYNRPDS YLANVSLHKL
RVDDGNSESL YKQVVTVKSL ASDSLPRPES EDESSESEIE EVSEKDAFFW MSFESNPLDD
IADTNLFIKM KSITVFYNTL FFENVMRFFH PPKIHLETLG AILNAANATV EELRDQTRIG
LEYALQEHKT VNLKLDMQAP LIVMPLDVFS WSSPCAIIDA GHISVVSHLV GKEVIEEVKK
KKTLQYTDSD WKRLESLMYD KFNLKLHNTQ LLIGSNVRDT MKQLHNGVSD ATASVLDRIN
LDFLIEVSIL PDAQSLTKFK MSGTLPLFQA SMSDAKYKIM MQLIDKGIPN FSFDDLIEPD
ESETPESNDK AVLIGNRINQ ELPEYVHDDS ASEDSVGAEP LSASSRVSTQ KIFEFNFKVE
KMNMALHRCT SIETLAQEPV VDMNLDSFEI CYYYKEKEMM ADVVVQNIDI EDYTQKDVPV
ELTKLATSIP TDTSPSDFFN VKYKRIKTDH VDRFDQQISD QDIVVTMSAM KYVVSPKTFL
TILDFIITTF TNPQPQQLPP ASNHLDGTLT PTGEVEPVAK IDVKVNLSSI TILLNDDGIK
LATLQLDSAL VNVFLVPEKM KVEARVGKLS LHDEVNEGSA RNSILRQLIS IEGNDLADFK
YETYDPSSSD FHYNSSVYLR AASMRFNVVE EPFARIVKFM SKFVQMKALY DSARQATVAQ
ANQIQIEDAN KIHFDILVST PIVVIPKLVE FSDDSLCDMV VAHLGEIYAK NEYIHFPEDP
NGPLANHMSV GIRDIKLSSN FNFPNGTNQY LEMIDKLDLT LDMSFVQPYE TMTRPVTVIS
GNLSDTSMKF TEMQYKFLMQ TSSILSTIFS GEPGIQEQEL DQLEEELRAQ KNLQPVAVIR
VPELPPVPAS VNKLDLSFYA KKIQLCLYNK TEEVMTDKLE KCSLTRFSLN DAGIKLRMKQ
NSDMESDIHI KSFTVHDTRS VKENMFTEII PGIKHDEYQF LCNLTMTGQE KRKLKAILTV
DSPSMILALD YLFALREFLF YGLATSPESI PELDDEEYEE ESEYESSEDE TSQLPARPGS
APQSNLTIEY HINIVDASVI LLANPKLEDS EAIVFKAEHF ILSQQATMVL SANKVGMFLC
RMDNFERNRL RLLDDFSLTT TMDNRGSSPN SEICKINISC EPLVLRLALR DVMLALDIVK
RASALFTQTE SQTETPSKFK EPIKYSRFSK LQKSRSSAVS KSYATSFGGR SRNSLRGRRD
SGSTSRVIVP IIRGQTLLAE FEGLRFVLIG NIHELPMLDM CTKPFKVKVR NWSSDLTIDS
GIETFVNIFN YEKSAWEPLI EPWDLGLHVA RSIEDNNTAI NLYSRKMAEI TVTSQTISIV
DNMMKFLSED AEEFLAKSIG HIAPYRIVNQ TGYDLEVWID HSDRDDIKNT TVIKDNEEIP
WRFYDWNTVR ENLSTDTQKV NLGVALKNSP FDPIRNMSVT SVGEHIHTLY PKTDKVSHRL
MCEVVMDESV KRIVLRSALT FENKTQIPID IAIGPSNNES FMCRIKPGQS RAIPIEHAYD
KAVSIRPDPS FKFGWSREPM YWKNMLTGPK SISCLPLNEN SSTKFYFQAT AIYDKSIPLT
RIYPHMKIVL SPPVEITNLL PFDFTYRIYD KKTGQDWGNT LKQGATGAVH VVELSHLLLL
NVHPKEAGYN CTDFAIINTP KKDFSLEHRL LTRSTDGQRL VLKLHYIDDK ANGGGCKVQV
YTPYLILNKT GLDIKVQTKF NTATSRVHSI AQLHNGKETF MKIASPQMWS FDSDDRGNRA
TIRVGDSKWS EPLSFDTLGK DSDVTIPSST RQSEIHVGLH ISEGPGKYQM TKIVTLTPRF
IINNKLSYDL QIKDSGSTLI VVGAKSLQPL HFLRRAEQQQ LSASFQGSSS VWSAPFNIEN
IGCTFLRMYQ HDVGYVLLKI DILLENATLF LHIDKADKNW PFSIRNFTNH TFQFYQANPY
VDDRGIELAQ HPKFTPVLYQ IPPKSVMPYA WDYPAAPLKE LVLNANGKER RIQLAEIGNL
QPMKVPSTSD RPGGIVDLNV VADGPTQTLV MSDYDPSISL YKMNTQLTSS KSSVVPTEQF
SVQDDEGEIQ SSITVRFEGI GVSLINRRMQ ELCYMTLRGI EFQYKCSEIY ETFSMKMKWM
QIDNQLYGAI YPILLFPSVV PQTGKEMDTH PTFSGSITKV RDDSHGVFYL KYATILLQQL
TVEMDEDLLF SLIEFFNSYK PTNDDDKVVL CDPQLEIPEP LTDTSGLDFY FEVLHIQPAQ
MDLSFVRTER LNSEERASSD NPFMFFFNAL TMALGNINDA PVRLNALVIE NVRTPLPLLM
QSISTHYRQE FFYQIHKILG SADFLGNPVG LFNNLSSGFM DMFYEPYQGY IMNDRPQEFG
IGLAKGGLSF MKKSIFGISD SFSKFTGSIS KGLSAATMDR AFQDKRRMKR ARNRPKHALY
GITSGANSFV DGITSGVSGL ALAPVQGATE GGALGFFKGL GKGIVGLPTK TALGFFDLAQ
SVSEGVRNTT TVFDGNAIDS VRPPRFISLE GIVRPYSQRE AQGQAWLKVA NNGEFFRDNY
LAHLSLADDE MIIIITYLRI MLLSTATMAT EWEVRFRDLQ TIAMERTGLA LILRGGVQGP
FIPIPDTPSR KFLYKEIGVA VTEFNRKYQT LS
//