ID A0A0J9XF02_GEOCN Unreviewed; 1919 AA.
AC A0A0J9XF02;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=BN980_GECA13s00802g {ECO:0000313|EMBL:CDO55957.1};
OS Geotrichum candidum (Oospora lactis) (Dipodascus geotrichum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Geotrichum.
OX NCBI_TaxID=1173061 {ECO:0000313|EMBL:CDO55957.1, ECO:0000313|Proteomes:UP000242525};
RN [1] {ECO:0000313|EMBL:CDO55957.1, ECO:0000313|Proteomes:UP000242525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 918 {ECO:0000313|EMBL:CDO55957.1,
RC ECO:0000313|Proteomes:UP000242525};
RA Casaregola S.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; CCBN010000013; CDO55957.1; -; Genomic_DNA.
DR STRING; 1173061.A0A0J9XF02; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000242525; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CDO55957.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1338..1528
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1625..1903
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1629..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1919 AA; 215376 MW; 2A38C24FA91A4234 CRC64;
MDDFGISRKG RGIRAQALER LSRLSASDPK KAESLDKLTG ALTYSDNSLN GSTTAISAKE
LEILLALARS ASFIQDSTQA LKLTRLLGRY LCENPSQKIA NSATNREVRP SPWQVSSKCL
TRAILNLGYK FQTDNDIFTE SQSILSRYLD ITFSAFLTAE TFDNQASFFP LLFSVQGFLE
AITDKITIVP YSFIQKLLIK SREVFTTEFL LALETTIAKT SSNLSREEYA AALLSIRTAR
SSDFIWSYYA ESYSRFNKPL GAMQFSSYLC DLALAVSSKI IDTSELPSAN LIDRLLSVEK
LAKLTEQQYD ILDLVTDYAV DQITSLDEGA DYIELASPEK IDLAYATKAS ALQVIGVAVY
FKHFSVEEAV KLVISSISHE YGMSNNLLSV TVFKLASLLC LFHDEIGGVV IKYFSHFITL
PGVNASLVQK CAETLVFGLK TLSQDVVVST IYTFINLLSV DHDAVSPPIP AKGYHDQASG
SAVGTEDTPS PDSYSTALYR NAITAVVTIA SKYGDPQIAG LASTVLNQKL NSSLVLDREV
ALGMADLVMF VNEKEFRTIW KSFTFLLNNS FKSKDNESGD LISEVLYKLS TNLDRNHYLY
DSYLAELLQA IVNRGDVHEL EHHRPHVEIS ATANEISIFL APLATLLPGL YEAPYETADN
EINDLFRNAW FNMVVHGFSK NSDLTAKYKN ELEIIARSTP PLVSEVSTNK IESELELNTV
LQRGSSHHNV NNQKEIMESI TSSNIFDFRN IQYPKLMFLS ATVLLESLRA NTGNCSKSLL
YFGDPGIRNG ETRRYMAFIT MDVVKAYITN VIKGGIPYFA IDKVAAQLKE MFVFCCHRVK
SIQDMAFECC NILIGSVPSA LCQKISLFAL LDLLTLLWSS CIDADTDEYE PRSIFHTKNT
NIRLELSDSY DHRRESLQRL LVKAKEWVTV ALETMNFDVK NLLTSYLNDM NSSRPLNDVA
LGFTFALEMG GSVSGSDREL AAISKASNIS TDTSSGFLSQ FIWSREIRAL PNFATSQEAI
ALYDKEAVEI RQKLDTLFVN INSHAHGTSH VHFTEAKSLI FKASGFFTHK SEGRNIARLC
VKIPFRVFTE SSIQFGITLW LWAINENPSL KPLILSEVSQ LWEWSVGECH GIYTRRHDLV
DAADAKMEYS PSNKAEINHD AALASREFSC HQQLMRFLSS AFKSSIYESS HLLKMFTRLL
TVGLEGLNHA SFHPLARPAR FELIQFSLDV LEVHTRLSSS NVVHSLKDLI ISSALTWFSQ
PSQWPFGGNK LKLRADVDLL SKIAVTLKSM YISTNSKSQA FVATKRDLLL YFMADELAKM
TAWLDPLQTG PNFRDNLGKK LIPSFTVSVN VLNNAWDIDP VLAVYLVERF KSNDLASRLE
ALIGKSPLKV VSVPEALPYF LRARNSRKVD ASVDHQLVYW ASVSPIDSIN LFLPSYHADS
LLLQYAMRSL KSHDVDITFF YVPQLVQSLR YDVSGYVEQY ILETAQISQL FAHQIIWNIL
ANLFKGDDLP ENTAEDSVNP ILERVIKRMT SAFKDEDREF YEREFTFFNT VTGISRSLMP
YLRKTKAEKK AKIDEEIAKI VVDEGVYLPS NPDGDVIDID RKSGRPLQSH AKTPFMATFK
IRREVRDLGE GENSAAGAVS ANDNDDDEED GERTKTIEVW QSAIFKVGDD CRQDVLALQI
ISVFRSIFNS YGLDLYVFPY RVTATAPGCG VIDVLPNSIS RDMLGREAVN GLYEYYTTKH
GGEDSIQFQR ARNNFVKSLA AYSVISYLIQ FKDRHNGNIM YDDQGHILHI DFGFCFDIVP
GGVKFEAAPF KLTHEMVAVM GGSTTTQAYR WFEELCVKAF LACRPHSETI IKVVLPMLDS
GLPCFKGEST IKRLRNRFVL DKTEREAALH FRGLIKKSFE SVYTKGYDEF QRITNGIPY
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