ID   A0A0J9XHS6_GEOCN        Unreviewed;       664 AA.
AC   A0A0J9XHS6;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=Kinetochore protein NDC80 {ECO:0000256|RuleBase:RU368072};
GN   ORFNames=BN980_GECA18s00362g {ECO:0000313|EMBL:CDO56973.1};
OS   Geotrichum candidum (Oospora lactis) (Dipodascus geotrichum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Geotrichum.
OX   NCBI_TaxID=1173061 {ECO:0000313|EMBL:CDO56973.1, ECO:0000313|Proteomes:UP000242525};
RN   [1] {ECO:0000313|EMBL:CDO56973.1, ECO:0000313|Proteomes:UP000242525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 918 {ECO:0000313|EMBL:CDO56973.1,
RC   ECO:0000313|Proteomes:UP000242525};
RA   Casaregola S.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000256|RuleBase:RU368072}.
CC   -!- SUBUNIT: Component of the NDC80 complex.
CC       {ECO:0000256|RuleBase:RU368072}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000256|RuleBase:RU368072}. Nucleus
CC       {ECO:0000256|RuleBase:RU368072}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family.
CC       {ECO:0000256|ARBA:ARBA00007050, ECO:0000256|RuleBase:RU368072}.
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DR   EMBL; CCBN010000018; CDO56973.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J9XHS6; -.
DR   STRING; 1173061.A0A0J9XHS6; -.
DR   OrthoDB; 5490442at2759; -.
DR   Proteomes; UP000242525; Unassembled WGS sequence.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:UniProtKB-UniRule.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   Gene3D; 6.10.250.1950; -; 1.
DR   Gene3D; 1.10.418.30; Ncd80 complex, Ncd80 subunit; 1.
DR   InterPro; IPR040967; DUF5595.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; KINETOCHORE PROTEIN NDC80; 1.
DR   PANTHER; PTHR10643:SF2; KINETOCHORE PROTEIN NDC80 HOMOLOG; 1.
DR   Pfam; PF18077; DUF5595; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368072};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618,
KW   ECO:0000256|RuleBase:RU368072};
KW   Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU368072};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU368072};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU368072};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368072}.
FT   DOMAIN          258..325
FT                   /note="DUF5595"
FT                   /evidence="ECO:0000259|Pfam:PF18077"
FT   REGION          1..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          299..423
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          518..552
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   664 AA;  76839 MW;  BC704079D8ED7DF0 CRC64;
     MNPQSSESLQ RGPQRTSMNP PHNSKSMLPT ARNSLTSNHR RSGSSRLSVI SNPRNSLAPG
     RSTPYSRGTP TLSEMMAASV KRTSMRSSGI GFSQAQQHQG SGGRNRLSMA PGFTTPSGSN
     NSTSRDTRPL RDKNYQAKIS QETFDYLVKN KFEIETRHPL TQKTLKAPTQ KDFALIFQWL
     YKRLDPGYKF TRSIEHEVYS ILKIINYPFL DSINKSQISA VGGQNWPYYL GMLHWLVELN
     RSLDAFDNKA YGTENYTEDD VLDQIFIRYI SKSYKAFLSN EDDYSEYKEE MIQEFDDHSL
     KIKEKMADMK EDSDKLEKKL QQMEKSAEQI HSLESKGEAL EGDLLKFKAY IESMERRKMK
     WEGVLSKIKE ELDAADVELK EVQETKANLD LKIKEQGLEP ADIDRINAER EKLGKSLERV
     NASLEEMTRI SKDKELAAQN ELENLEILIH SYNDVVYRLP ARPKDSTGNE IDLSVSLNAP
     LAEENLGQPP EKIVKGKYMI REIRPLLQKF RFDISDNVRK LQDEMIQEQD QLDKMSEDII
     EKQDEITRLE AKLKLTRISH DTLVETMQAE TAASNAEIEK MTHELQRMEL AFKQSQLQLE
     QRRQSTAIKH EKVQQFVQHE RERMHEKVRQ VIFKVTDFKV GIQELLEKYE KFVLDEWDNT
     VANE
//