ID A0A0J9XQC2_BRUMA Unreviewed; 922 AA.
AC A0A0J9XQC2; A0A0K0JF95;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=BMA-NPP-9, isoform a {ECO:0000313|EMBL:CDP93481.1};
DE SubName: Full=BMA-NPP-9, isoform c {ECO:0000313|WBParaSite:Bm4572c.1};
GN Name=bma-npp-9 {ECO:0000313|WormBase:Bm4572a};
GN Synonyms=Bma-npp-9 {ECO:0000313|EMBL:CDP93481.1};
GN ORFNames=Bm4572 {ECO:0000313|WormBase:Bm4572a}, BM_Bm4572
GN {ECO:0000313|EMBL:CDP93481.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP93481.1};
RN [1] {ECO:0000313|EMBL:CDP93481.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP93481.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP93481.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP93481.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm4572c.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
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DR EMBL; LN856875; CDP93481.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J9XQC2; -.
DR EnsemblMetazoa; Bm4572c.1; Bm4572c.1; WBGene00224833.
DR WBParaSite; Bm4572c.1; Bm4572c.1; WBGene00224833.
DR WormBase; Bm4572a; BM47951; WBGene00224833; Bma-npp-9.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR CDD; cd00835; RanBD_family; 1.
DR CDD; cd13179; RanBD_RanBP1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR InterPro; IPR045256; RanBP1_RanBD.
DR InterPro; IPR001876; Znf_RanBP2.
DR PANTHER; PTHR23138:SF169; E3 SUMO-PROTEIN LIGASE RANBP2; 1.
DR PANTHER; PTHR23138; RAN BINDING PROTEIN; 1.
DR Pfam; PF00638; Ran_BP1; 2.
DR SMART; SM00160; RanBD; 2.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50196; RANBD1; 2.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 135..268
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 310..339
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 592..723
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..804
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 99318 MW; 961CD4C3F441132B CRC64;
MTKPASATTP IATSKEVPSQ QVQSQAVLGN QIKTSAPFTF GASVKQGVST VATTAVTTTS
VLAKPFSAGT ITTSNTSSGS FANLFSSPKA TQIEAEKKDD WENSLPKNAG SEALTKNESA
GDDDEAPEHF EPSIHFEPIV PLPELVELTT GEENEVVKFA GRCRLFRFVD NEYKERGIGM
LKILENPKTK ICRIVMRRDQ VHKVCANHTI QATMNLTPLQ KSDRAFVWLA QDFAEEEKME
KFAARFKTVE IAKNFEAMFN AARDAASSAD NKGGTVKTTS CDKGERKELK GSEGEKNDSM
KGFGDAFKPP AGSWSCNACY ISNTVNATVC ICCGAAKDGG SDSTSASSVF SSKPTSTVAP
IKGSSGITFG FRSDSSPASV TTTATTFNSG LPTFSFKPAT TTTASANVTT TAAQPLFSSF
VSRPMTTTTT TASSVFQSVT TTTTATTNAS SAPSVPNFSF KFTPSNSTAF GGPPCFGTKS
PSTTSSTAGT NESTTVNTKS SLFGSSAFSG GSVFGKSSSG GFAALAAKAK SETSAKSAEG
NKVITPFGGG KFDTSMNSIF SSNAKQNTPK EKNEEGAEDN SDDAEEFEPN AHYEPVVPLP
SLIEVKTGEE GEQVMFKARS KLYRYVAETK EYKERGVGDI KILFNPETKR CRIVMRRDQV
LKVCANTPIT DSSSIKKKPN TDNACMWMCR DYSEEKEGVN EYFVAKFKDA SLADEFILAF
QNAAARKFPL QDQKNASAAG DGTSPKISGT CKKLEASLNN TSQKQNRNVG KGSEHTGDKS
KKDSADVEND YDDGENDGDD DDEYEELSTH KVKATISEAY ASPLKPSKPI EFTGFIALGL
LGSGHMKIDL YNDDEQMQWS HVIELEDGLS RQNKNQIKYV AMDEKSQSKQ VVLEFTNEME
CEKAYLDLEE GIHLLKEYSD QE
//
