ID A0A0J9XQZ3_BRUMA Unreviewed; 409 AA.
AC A0A0J9XQZ3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=26S proteasome regulatory subunit 8 {ECO:0000256|ARBA:ARBA00040909};
GN Name=bma-rpt-6 {ECO:0000313|WormBase:Bm13756a};
GN Synonyms=Bm1_21785 {ECO:0000313|WBParaSite:Bm13756a.2};
GN ORFNames=Bm13756 {ECO:0000313|EMBL:CDP93275.1,
GN ECO:0000313|WBParaSite:Bm13756a.1, ECO:0000313|WormBase:Bm13756a},
GN BM_Bm13756 {ECO:0000313|EMBL:CDP93275.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP93275.1};
RN [1] {ECO:0000313|EMBL:CDP93275.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP93275.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP93275.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP93275.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm13756a.2}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914, ECO:0000256|RuleBase:RU003651}.
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DR EMBL; LN856867; CDP93275.1; -; Genomic_DNA.
DR STRING; 6279.A0A0J9XQZ3; -.
DR EnsemblMetazoa; Bm13756a.1; Bm13756a.1; WBGene00234017.
DR EnsemblMetazoa; Bm13756a.2; Bm13756a.2; WBGene00234017.
DR WBParaSite; Bm13756a.1; Bm13756a.1; WBGene00234017.
DR WBParaSite; Bm13756a.2; Bm13756a.2; WBGene00234017.
DR WormBase; Bm13756a; BM30801; WBGene00234017; Bma-rpt-6.
DR OMA; TANCRVA; -.
DR OrthoDB; 360215at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd19502; RecA-like_PAN_like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032501; Prot_ATP_ID_OB_2nd.
DR PANTHER; PTHR23073; 26S PROTEASOME REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR23073:SF166; 26S PROTEASOME REGULATORY SUBUNIT 8; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF16450; Prot_ATP_ID_OB_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU003651};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003651};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 185..324
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 31..72
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 409 AA; 45663 MW; 0B2428638FF0EDE3 CRC64;
MAPPMAGLIS TGVASKSGEE QSLKRYYKTK IEDMQQRVAE KTQNLRRLHA QRNELNTKVR
MLKEELQQLH EQGSYVGEVS KAMDKKKVLV KVHPEGKYVV DLDKGIDINS ITSGCRVALR
ADSYALHKVL PNKIDPLVSL MMVEKVPDST YEMIGGLDKQ IKEIKEVIEL PVKHPELFDA
LGIAQPKGVL LYGPPGTGKT LLARAVAHHT ECTFIRVSGS ELVQKFIGEG ARMVRELFVM
AREHAPSIIF MDEIDSIGSS RVEGSSGGDS EVQRTMLELL NQLDGFEATK NIKVIMATNR
IDILDPALLR PGRIDRKIEF PAPDEKARAD ILKIHSRKMN LMRGINMRKI AEAIPGASGA
EVKAVCTEAG MFALRERRIH VTQEDFEMAV GKVMQKDSDK NMSLKKLWK
//
