ID A0A0J9Y9T7_BRUMA Unreviewed; 1455 AA.
AC A0A0J9Y9T7;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=BMA-ZYG-9, isoform a {ECO:0000313|EMBL:CDQ05377.1};
GN Name=Bma-zyg-9 {ECO:0000313|EMBL:CDQ05377.1};
GN ORFNames=Bm3504 {ECO:0000313|WormBase:Bm3504a}, BM_Bm3504
GN {ECO:0000313|EMBL:CDQ05377.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDQ05377.1};
RN [1] {ECO:0000313|EMBL:CDQ05377.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ05377.1};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ05377.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ05377.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR EMBL; LN856671; CDQ05377.1; -; Genomic_DNA.
DR WormBase; Bm3504a; BM47976; WBGene00223765; -.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0099080; C:supramolecular complex; IEA:UniProt.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 3.
DR SMART; SM01349; TOG; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 3: Inferred from homology;
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 5..243
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 178..216
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 285..523
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 458..492
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 627..865
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 535..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1455 AA; 163843 MW; BC0A814AA7C8985D CRC64;
MDDWSLLSEV NVLVKLPEQF NEWLESKKWT ERRDALQALI NEMTKTPRLD PKVDYFSITQ
SLRNVLAKDA NINVCALAAK CITGLANGLR MKFAQFATLY IPVIFERFKE KKPTLRDPLI
ECIDTIALTV NLDMLVDELS NCFNKPNPQI KLQACNFIYR VMKNHNQTSA PKKTIKAVTP
ILVKFTTDPD AEVREAACIG LGSIMRLTGD KVMNTFLGNL QEDKTKMKKI CDSRDQATAE
YNEEAMRKKE SVPCGSTAIP STDAVVVGRM TTSDEACVQE IDPWDMLDPV DVLAKLPANF
MESIDSKKWV ERRDALQSLL VLCTENPKLC PKANYGEFVA LLKKILEKDA NINVCALAAR
CLTAFATGLR KKFAQYAIMV APTIFEKFKE KKPVLRDPLI DCIDAVAAST TLEALAEDIQ
TALDKQNPHI KIQTNLFLYR VFKQHNPQTV PKKILKLLAP IIVKLTGDSD PEVRDASYAA
LGAAMKAVGE KSCMVLLADI AEEKVKMAKI RDFCEKALQE AGTDVVSIMV QSMHKSNPLK
PPAPGVGNSS VSEKTRSKEV VNEDNTEEKS SKATRKEFEA AKEPEESVKP RDEFLVINKD
KGIRLKDERN LRACFFVLKW NFDQPENEHI EQLKTLLGNV TQASLLTLLF NKDFKQQLKG
IDILQSLITD CPESLISNSD LLLKWISLRF LETNPTVLLK VLDLTQGIFN LLLQHNEPFS
DQEMYSFVPY LLLKLGEAKD SVRTPVRTII QLVTELVSPP KIFPLIIEGL KTKNSRQRTE
CLQVLEQLLD TTGMAATTTP AQSLKQIAAC IDDRDNNVRN AAINAIVVAW KEEGDRVFQL
IGKMNDKSKA MLDERIKRSG VVSKARGGPE RVGTSAKRNA NISVGIKGRR LRSDRSSSRI
GRNTHRSNSV SRDSSPVEEK ENNRTFTMQE RDLGSHSDDN DGTRRRFALN LDLLKLDNND
EAVVYPEVDS NTLEMLEPIE PAIRKRRNPP QYADRAESVS SLTSLESAAG DVDKVVHGVA
SMSQATATAA ISQLQFLFGD PSNFRYVADR TDAVVQAIVT QSSIIRSRHL DDVSALDELN
ELVRTICHFL SSLIKETTTC SRISSDALKM LIQEFLYLLK DERMQQLKDI QSIFRSLNYL
SIRICDNADP TACFLALCSM LTSALHDPRN KTVELINKCI YKQSELFLRD VPMNLDEIVK
AIHIFMQEFR PRIDENKNIK NSLHSMELCI QRLVAGTKSS VIQHIGEIPN PDSSEAVIYM
RKCVRGLQNK SNQNSLASSA YGELPGQVVS SNYEDSIRNL ISKIVENPFG KGLRFLHTFL
KMNPDARKVL EEELKKHFRM RDFITLHLKK MDLEDRETPE VTDELYNVME SIRAHREALR
SYRQTGWWTG SAASALATST DENAKPMTVR RSFQRQPLEG APENEPVTPV PTKPKLTASD
VEPLKQLLNM RRQQQ
//
