ID A0A0J9YAD2_BRUMA Unreviewed; 1115 AA.
AC A0A0J9YAD2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
GN Name=Bma-slo-1 {ECO:0000313|EMBL:CDQ05099.1};
GN ORFNames=BM_Bm6719 {ECO:0000313|EMBL:CDQ05099.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDQ05099.1};
RN [1] {ECO:0000313|EMBL:CDQ05099.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ05099.1};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ05099.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ05099.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LN856618; CDQ05099.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J9YAD2; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF33; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 2.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 51..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 139..357
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 508..573
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 574..624
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 983..1099
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
SQ SEQUENCE 1115 AA; 126316 MW; B482210BBC42AB8C CRC64;
MSDVYHPGSG GSKGFPPAPY GYPMHCNMSR AFQEMTDDER KCLDERKYWC FLLSSIVTFC
VSMLLVVIWR IIAHIFCQRR EREETDAVFD QDEGKHELLK GDLDGIAIKQ EEVQIGWMTE
AKDWAGELIS GQSMTGRILV VLVFVLSIGS LIIYFYDASH PNFQVETCVS WSDSPSQQID
LGFNIFFLIY FFIRFIAASD KVWFLLEVYS FIDYFTIPPS FVAIYLERNW LGLRFLRALR
LMTVPDILQY LNVLKTSSSI RLTQLLSIFI SVCLTGAGFV HVLENSGDPF KNFANTHRIT
YWDCVYFLLV TMSTVGYGDI YCTTFLGRLF MVFFILGGLA MFASYIPEIA DLIGSRQKYG
GEYKGEHGKK HIVVCGYITY ESVSHFLQDF LHEDREDVDV EVVFLHRVPP DLELEGLFKR
HFTKVEFFSG TVMDSIDLSR VKVDEADACL VLANKYSSDP DAEDAANIMR VISIKNYSSD
IRVIVQLMQY HNKAYLLNIP SWDWRRGDDV ICLAELKLGF IAQSCLAPGF STMMANLFAM
RSFKTSPHTP PWLNDYLRGA GMEMYTESLS HSCSRNTPDW LNLYLCGAGM EMYTDTLSHG
FVGMTFPEAA DLLFTRLGLL LLAIELKDDE KKECNIAINP APTTTIQPQT QGFFIAQSAD
EVKRAFYWCK QCHEDIMDIS LIKKCKCRNS RATPVSNASN DTAVQLRRLD ERRSFGQKNS
LSLPPENRTI DFSKEFEQQD MKYDSTGMFH WCPARTLEEC VLDRHQAAMT VLNGHVVVCL
FADRNSPLIG LRNFVMPLRA SNFHYHELKH VVIVGDVEYL KREWKTLYNL PKISILNGSP
LSRADLRAVN INLCDMCVIV SARIPNPNED PTLADKEAIL ASLNIKAMQF DDTLGFYPLR
QTGGTVSPLG SPLSLQKKGA RFGTNVPMIT ELVNDSNVQF LDQDDDDDPD TELYLTQPFA
CGTAFAISVL DSLMSTTYFN DSALTLIRTL VTGGATPEME LILAEGAGLR GGYSTPETLN
NRDRCRISQL ALQDRPFEGI TTGSSYGQMF STALKKHGQL CIGLYRLHDQ AAVDSNKRYV
ITNPPAELRL LLSDYVYVLE QFDPGLEYEP RKNFL
//
