ID A0A0J9YUS5_MOUSE Unreviewed; 1303 AA.
AC A0A0J9YUS5;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Eukaryotic translation initiation factor 4, gamma 1 {ECO:0000313|Ensembl:ENSMUSP00000144320.2};
GN Name=Eif4g1 {ECO:0000313|Ensembl:ENSMUSP00000144320.2,
GN ECO:0000313|MGI:MGI:2384784};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000144320.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0007829|PubMed:18630941}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18630941; DOI=10.1021/pr800223m;
RA Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
RT "Specific phosphopeptide enrichment with immobilized titanium ion affinity
RT chromatography adsorbent for phosphoproteome analysis.";
RL J. Proteome Res. 7:3957-3967(2008).
RN [3] {ECO:0007829|PubMed:19144319}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4] {ECO:0007829|PubMed:19131326}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000144320.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144320.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [7] {ECO:0007829|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [8] {ECO:0007829|PubMed:24129315}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24129315;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [9] {ECO:0000313|Ensembl:ENSMUSP00000144320.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144320.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR RefSeq; XP_017172409.1; XM_017316920.1.
DR SMR; A0A0J9YUS5; -.
DR jPOST; A0A0J9YUS5; -.
DR ProteomicsDB; 345565; -.
DR Antibodypedia; 3406; 709 antibodies from 37 providers.
DR Ensembl; ENSMUST00000143939.8; ENSMUSP00000144320.2; ENSMUSG00000045983.17.
DR AGR; MGI:2384784; -.
DR MGI; MGI:2384784; Eif4g1.
DR VEuPathDB; HostDB:ENSMUSG00000045983; -.
DR GeneTree; ENSGT00940000154648; -.
DR BioGRID-ORCS; 208643; 7 hits in 65 CRISPR screens.
DR ChiTaRS; Eif4g1; mouse.
DR Proteomes; UP000000589; Chromosome 16.
DR Bgee; ENSMUSG00000045983; Expressed in lacrimal gland and 257 other cell types or tissues.
DR ExpressionAtlas; A0A0J9YUS5; baseline and differential.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF10; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A0J9YUS5,
KW ECO:0007829|MaxQB:A0A0J9YUS5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 944..1066
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1132..1302
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..184
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..926
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1303 AA; 145313 MW; 93B67E43C9D8FAD2 CRC64;
MTTGMIPMSV EESTPISCET GEPYCLSPEP TLAEPILEVE VTLSKPIPES EFSSSPLQVS
TALVPHKVET HEPNGVIPSE DLEPEVESST EPAPPPLSPC ASESLVPIAP TAQPEELLNG
APSPPAVDLS PVSEPEEQAK KVSSAALASI LSPAPPVAPS DTSPAQEEEM EEDDDDEEGG
EAESEKGGED VPLDSTPVPA QLSQNLEVAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA
FKEVDPAVPE VENQPPTGSN PSPESEGSMV PTQPEETEET WDSKEDKIHN AENIQPGEQK
YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHITDVVLDK ANKTPLRQLD
PSRLPGINCG PDFTPSFANL GRPALSNRGP PRGGPGGELP RGPAGLGPRR SQQGPRKETR
KIISSVIMTE DIKLNKAEKA WKPSSKRTAA DKDRGEEDAD GSKTQDLFRR VRSILNKLTP
QMFQQLMKQV TQLAIDTEER LKGVIDLIFE KAISEPNFSV AYANMCRCLM ALKVPTTEKP
TVTVNFRKLL LNRCQKEFEK DKDDDEVFEK KQKEMDEAAT AEERGRLKEE LEEARDIARR
RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG KDLDFAKAKP
RMDQYFNQME KIIKEKKTSS RIRFMLQDVL DLRQSNWVPR RGDQGPKTID QIHKEAEMEE
HREHIKVQQL MAKGSDKRRG GPPGPPINRG LPLVDDGGWN TVPISKGSRP IDTSRLTKIT
KPGSIDSNNQ LFAPGGRLSW GKGSSGGSGA KPSDTASEAT RPATLNRFSA LQQTLPAENT
DNRRVVQRSS LSRERGEKAG DRGDRLERSE RGGDRGDRLD RARTPATKRS FSKEVEERSR
ERPSQPEGLR KAASLTEDRG RDPVKREATL PPVSPPKAAL SVDEVEKKSK AIIEEYLHLN
DMKEAVQCVQ ELASPSLLFI FVRLGIESTL ERSTIAREHM GRLLHQLLCA GHLSTAQYYQ
GLYETLELAE DMEIDIPHVW LYLAELITPI LQEDGVPMGE LFREITKPLR PMGKATSLLL
EILGLLCKSM GPKKVGMLWR EAGLSWREFL AEGQDVGSFV AEKKVEYTLG EESEAPGQRT
LAFEELRRQL EKLLKDGGSN QRVFDWIDAN LNEQQIASNT LVRALMTTVC YSAIIFETPL
RVDVQVLKVR ARLLQKYLCD EQKELQALYA LQALVVTLEQ PANLLRMFFD ALYDEDVVKE
DAFYSWESSK DPAEQQGKGV ALKSVTAFFN WLREAEDEES DHN
//
