ID A0A0K0DEY3_ANGCA Unreviewed; 935 AA.
AC A0A0K0DEY3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Protein kinase domain-containing protein {ECO:0000313|WBParaSite:ACAC_0000947001-mRNA-1};
OS Angiostrongylus cantonensis (Rat lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae;
OC Angiostrongylus.
OX NCBI_TaxID=6313 {ECO:0000313|Proteomes:UP000035642, ECO:0000313|WBParaSite:ACAC_0000947001-mRNA-1};
RN [1] {ECO:0000313|Proteomes:UP000035642}
RP NUCLEOTIDE SEQUENCE.
RA Martin A.A.;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:ACAC_0000947001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A0K0DEY3; -.
DR STRING; 6313.A0A0K0DEY3; -.
DR WBParaSite; ACAC_0000947001-mRNA-1; ACAC_0000947001-mRNA-1; ACAC_0000947001.
DR Proteomes; UP000035642; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR CDD; cd00064; FU; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF566; EPIDERMAL GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000035642}.
FT DOMAIN 579..826
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 916..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..935
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 613
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 935 AA; 106779 MW; 0F7F979811E80493 CRC64;
MPSVIEAFSN TNVRCVYNFH AFVYLCSGTN NGRSLAGSDN RIEDLTLMYQ NCTRVYGNVE
ITHLTKTTLT NWTDVDFSRK LRIFEHIQEI KGYLLIYNVD IRSIDFPSLK IIWGDDLLDD
SAALTLSSNM ELKELRMPML RAIHKGNVRI ENSTFLCYLQ SKVDWNEACR QLSLDGACVH
QCPPMMVHDK KRGMLIPNPK GRYMYDRYCV TECPICRVTK VLTGSILRNL TGCEEIDGFI
DIQDSKMRRV ARIGVLCVPL SCAIFETYPS SSRSTDGYTR DDLNVLKSVR MISEYVQMAT
QTVSPRNLSF LENLEFIEGR SLVTSKFALA INKNDNLEQL GLRKLKKIKA GSVIITENHG
LCYAQTIKWD KIIASNAQAL ITKNMDGKCE ERRRICDETC DPALGCWGRG PTMCTKCRYW
QLQDTCVNEC PNEGCTGPGD HLGPGGCSEC LYAQVSREHE VIRCLFSLSM HEACRDVIGH
YPSTQPISGV QLVVCLAECP EEFPFLDEFK MCNRVDLNKE REKRSRMIAA IFATVFALLL
ISMLEQISNY VDIPEMTPVD PSIRSNMSRV NLITASELQT KGTQLGAGAF GVVYAGFWFP
KGKGKIKVPV AIKLVKGMRT GKEESEMLNE AMQMSSLRHE HLLRLVVSLF TCRIVGHFSL
QAMKYLYEHR VIHRDLAARN VLVKRHNHVE VTDFGLAKLL DYGQEKVKVM EGKVAIKWLA
LESLKDQSYT HRTDVWAFGV TCWEILTFGQ VPVHFRGCFF LQTFQSTTLV KSEDKDGNRL
SQPSNCSIEL YQVLLQCWMA NPESRPTFTM LHERFQNFCR IPHLYVEDQV TPQAFVETEC
QRDLLRELLN DTENDFTDPL NYFEMCENPE TPTADFETVC SSIVDRKEVV SKHEYYNEAK
HKAEYYNDIV STQSEKQQLQ VDEDTTEEMQ KESCL
//