ID A0A0K0DQJ9_ANGCA Unreviewed; 679 AA.
AC A0A0K0DQJ9;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Phorbol-ester/DAG-type domain-containing protein {ECO:0000313|WBParaSite:ACAC_0001403801-mRNA-1};
OS Angiostrongylus cantonensis (Rat lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae;
OC Angiostrongylus.
OX NCBI_TaxID=6313 {ECO:0000313|Proteomes:UP000035642, ECO:0000313|WBParaSite:ACAC_0001403801-mRNA-1};
RN [1] {ECO:0000313|Proteomes:UP000035642}
RP NUCLEOTIDE SEQUENCE.
RA Martin A.A.;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:ACAC_0001403801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
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DR AlphaFoldDB; A0A0K0DQJ9; -.
DR STRING; 6313.A0A0K0DQJ9; -.
DR WBParaSite; ACAC_0001403801-mRNA-1; ACAC_0001403801-mRNA-1; ACAC_0001403801.
DR Proteomes; UP000035642; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20810; C1_VAV; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000035642};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 7..117
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 210..406
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 592..642
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
SQ SEQUENCE 679 AA; 78283 MW; 3EEE2D533BAE101C CRC64;
MCTSERNELW KECVRWMVDM GVLDQRLAQT NSMLEFATML RDGVLLCRLL NELSPECVEE
KEIQRRPHMS ENICLFLGAC KTHFHLKQEQ MFEAWELFRL QDFAKVLSVL SMLSYSEAAL
QKNVKPFPST SSLSFSTVPP PRLHPPPEEE AIYRTLQDDL EKVDLGAAVY DISPLKNDEE
EPQFIYDHIV CRKDSQRRHD VWSSFSPSSK REHCMKELLD TEQNYVEKAL NMIINKFYEP
LQKVFREADH KLIFMNIMTL WNLHHSFYSD LRHAVLKTLG LIQPGEGRPN SLPLGNTIGD
VFVQHKDKFI AYGPYCMGLG ESRARILELE KSDPVAKAKI YECTSSVNDN QFKLQDLLCL
PMQRVLKYHI LLLELIKTTS FDAPDRKSLE LAKEAMDDVN SYVNEMKRDN ETKQLIVEVQ
NSITELTMLM IFSFAKLTEA SSLLVNYFQP EDVTLMDYGR LNADGEVRLA ESTNQQFGKM
KQRHVFVFDK VLIICKANRN NTYTYKSAYI ISELHPTLDN PMPDAKMGTI SRKIASTNQY
LLFLIREERA CTQDSVRHLT LAFKVLQQRE KWLHHFELAR GNVLPEQVDG TGHKVHYKSF
NVDVPYKCGV CEKFLKGLFF QGYKCENCGG LLHKGCIALR PCAGRRHATS VSHSNLSTNG
TQWRQSCHGR KLPVCTFSL
//
