ID A0A0K0E368_STRER Unreviewed; 886 AA.
AC A0A0K0E368;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Retinoblastoma family protein {ECO:0000313|WBParaSite:SSTP_0000393900.1};
OS Strongyloides stercoralis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000393900.1};
RN [1] {ECO:0000313|WBParaSite:SSTP_0000393900.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR AlphaFoldDB; A0A0K0E368; -.
DR STRING; 6248.A0A0K0E368; -.
DR WBParaSite; SSTP_0000393900.1; SSTP_0000393900.1; SSTP_0000393900.
DR Proteomes; UP000035681; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF36; RE32990P-RELATED; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 95..223
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 393..591
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
SQ SEQUENCE 886 AA; 103236 MW; E78B0443416330B7 CRC64;
MDEVMDTSCS VSTLHSYSQE SIPDQLAIKN EAYDNEAFEQ FKELVIKYLK PSEDCLTFTT
SRWEEFRSIK SRVTTVEPLL GWMVVYIHAF IIMYEDQGDK YPSHYEILDI AKDGDISIRD
FYSMLCKWMK FIDAPNRVLA KVDNVNSRIA VTIICFKKFL SIFYKLIKNI DSRHRPHRLW
CHETSLHIMW KYYIAFKQQV NCRNILMTAY HTLMCFFDYL CRRLREEGKI EMINQPYAEL
LNKNNTILDD LCKDFGGVPV ELKHFNEHTF YIKTEELVKL LKSKPSEKDY LDYLEETSVK
VMEDYTKAIL DERLLNETIF LDLDISKDQI DVIDANASLM LSSNGHPPPP KGSNFTSSQS
LEGLLSSIQK GKARTPLLTK TLYFDSESGC PTTPFSAANY KRTQLAMLID QYPPRPSKYL
EDLLDQFPDK PKNFIVNLFT KLSERFCSIV KEECRGDVTF DDQITDYAEE RTTSILALCF
RVLESLVTRE KQIIQDPTSE YWKILSQENF IRSVFNVALE LVLCAHNSLR DFPWSLRVTE
LQAINFSRII ELVIKANDHL AREFVKHLNI IEEKILEELA WTVDSPIWKV VGDGPANFPS
SYAVQYQAAD SSLSEIDRRQ MKDYENLVKN REKDATSVEP SSITQNTKIF VRKFYYLAAI
RVVHLCERLS FNEENKLKIW NCIEYLFRNH ITMLKSRHLD QIILCCCYVV AKVGRLEITF
NDILGAYRLQ PQACQAIIKY VFMENGPSIG PDEVKKDPKD FEGRRYNPND NLPGKRGHLI
SFYNKIFIEI MADIANKMRK ADDKIKSRIV PFPPLRQNPL SPRKQLTEHI TIVPQRNRDP
SNLQQPQQEK KTNVYMYTFY QSPSKDLDAI NKKVRDAGSN FNPRTT
//
