ID   A0A0K0E913_STRER        Unreviewed;       245 AA.
AC   A0A0K0E913;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000256|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000256|HAMAP-Rule:MF_03132};
GN   Name=EIF6 {ECO:0000256|HAMAP-Rule:MF_03132};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000599700.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000599700.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC       {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000256|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000256|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000256|HAMAP-
CC       Rule:MF_03132}.
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DR   AlphaFoldDB; A0A0K0E913; -.
DR   STRING; 6248.A0A0K0E913; -.
DR   WBParaSite; SSTP_0000599700.1; SSTP_0000599700.1; SSTP_0000599700.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:cytosolic ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   NCBIfam; TIGR00323; eIF-6; 1.
DR   PANTHER; PTHR10784; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; 1.
DR   PANTHER; PTHR10784:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   SUPFAM; SSF55909; Pentein; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW   Rule:MF_03132}; Nucleus {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW   Rule:MF_03132}; Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_03132}.
SQ   SEQUENCE   245 AA;  26471 MW;  AE255E099D564533 CRC64;
     MAVRCDYEGC NDIGVFTLLT NTYCLVGIGN SQNFFSIFED ELGDTIPVIH ASIAGTRIVG
     RMAVGNRHGL LVPNATTDQE LQHIRNSLPD SVEIRRIDER LSALGNVIAV NDYVALVHGD
     ISQETEKAII DVLKVEVFRT NLGEHSLVGT YCTFTSQGAL VAAKTSPEIQ KEISSLLQVP
     VVAGTVNRGS ELIGAGMVVN DWIAFCGSET TSTELSVVES IFKIGDNNPT QISTNLRDTL
     IESML
//