ID A0A0K0ED92_STRER Unreviewed; 1130 AA.
AC A0A0K0ED92;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
OS Strongyloides stercoralis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000745500.1};
RN [1] {ECO:0000313|WBParaSite:SSTP_0000745500.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A0K0ED92; -.
DR STRING; 6248.A0A0K0ED92; -.
DR WBParaSite; SSTP_0000745500.1; SSTP_0000745500.1; SSTP_0000745500.
DR Proteomes; UP000035681; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 460..481
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 490..508
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 545..573
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 694..716
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 746..765
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 785..802
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 846..866
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 872..892
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 940..959
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 116..377
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 431..923
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 235..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1130 AA; 126856 MW; 718C579E3B3BFD7E CRC64;
MGDKGDKDSR KQSETILQPS IIELDPQGGC QNVWMNMECH GKRSTTSIRN RRLSMRHQSL
DIDEAHDHLS PAAKIALILQ ENTALYPLFT EMSELKKIDG VEEWHESARW VKFEEDVEDG
GNRWSKPHVA TLSLHALFQL RSCIQNGIII LDDTSTGFAE LVENILDKLI DGEQLPEQLR
LDVKTVLLKR HKHQYENPRK NNEEGGMKGN SSTFLSAVRS ISDIGKSFSH ARSLAKSGEP
TINEDGTLGV PGDKKPPQVG NVHFMKKLHH DTEGCNVLVG ETDFLQHHIT CFVRLKKSVN
FGSITEVPVP TRFLFLLLGP AGHANEFHEI GRAISTLMTD DIFHDVAYMA RKNEDILHGI
DEFLDNVCCL PPGEWDPKIR IEPPSSLPSQ EKRKQAGMEY LQLPKSTVTK FKEEVEIEGH
GNDPALKRTG KLCGGLVADI KRKLPHYISD FTDAFNLQCM ATICFMYFAL LAPIVTFGGL
LEEATHQRMA AMENIFSGAL SGVIYHFFSG QPLTIIGSTG PVLVFETIVF DLCKGTLGGI
DYLSFRFWVH IWTAAILMVM VVTDASSLVS YITRFTEESF ATLIAAIFIF EAIKKLFNIT
HQLDIIPYNP INGTSGDCYC VGGNSNFDKI LHIAEKQRLT KYIDIESRSV DWTKIPMEKC
RILGGHAIGG TFIIATTLKK ARTGQYFPTK IRQIFSDFAV MIAIVIMTII DVLVGINTPK
LNVPSTFRPT WEGRGWFIPP FNGNSWWTVP VAFVPALLAC ILIFMDQQIT TVIVNRKENK
LKKGCGYHLD LFVLAILIVI AGFLGLPIYV AATVLSINHV NSLRIESESR APGEVAQFIG
VREQRLTGIF TFALIGMSVM ITRLLSYIPM PVLYGVFLYM GISALGGIQL YERLKLFLMP
MKYQPDTIYI RHVPIKVIHA FTGWQTACLI ILWGVKSYKL ISIAFPIMLV VMVAIRKLME
KFFDPKDLKY LDDPMPDFHL RKKEDARRVS LKAAEEIELD LDKNQGTIRA VKTEAHIHIP
FNNGEVVSIP LEAISGPSHN INLSKEVNSS SMWKHISHES KSSLNKMSEL YGGMSNDSVN
KFPIIEDDDE DAIIIKVNKN ENHNKNNDNP SNLESQPLLR KESKSSSNNK
//
