ID A0A0K0EDG7_STRER Unreviewed; 603 AA.
AC A0A0K0EDG7;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364117};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU364117};
OS Strongyloides stercoralis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000753000.1};
RN [1] {ECO:0000313|WBParaSite:SSTP_0000753000.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU364117};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364117}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446, ECO:0000256|RuleBase:RU364117}.
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DR AlphaFoldDB; A0A0K0EDG7; -.
DR STRING; 6248.A0A0K0EDG7; -.
DR WBParaSite; SSTP_0000753000.1; SSTP_0000753000.1; SSTP_0000753000.
DR Proteomes; UP000035681; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF159; ATP-DEPENDENT DNA HELICASE Q5; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364117};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU364117};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364117};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364117}; Nucleus {ECO:0000256|RuleBase:RU364117};
KW Reference proteome {ECO:0000313|Proteomes:UP000035681}.
FT DOMAIN 104..278
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 326..484
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 603 AA; 69860 MW; 3323E0D867347A14 CRC64;
MLNLDNWLIR SKKNPQQSKD IEVIENVVKE SKPVLKKSTK KTLKKKDEKK NLEDINELKM
LETNKTVLSE EFLNMPIEKK AEFVLRKIFK HKEFRNKDQE EAIHAAIARD SDIYISFPTG
AGKSLCYQLP ALCKAGVTIV FSPLIALIQD QVTALEQKMI KCCSWNSTLT NEERSRISKD
LFSASPKYRI VYTTPESAQT EFFQEMLKQL YKNDLLNYLV VDEAHCISQW GHDFRPKYSK
LSILKKITPG VPWIALTATA SCAVEKDIKM HLMFDNYKFF KTSPYRSNLY YDVITEGQLK
HEALMNENTD IETSNEINIQ NHIALYIKEI KEKLIKENGN DFNGYGGIVY CRSRDLCEQL
TEYLLSKDIL AATYHAKLKK NEKIEVQQKW MKNEISVICA TIAFGMGIDK ADVRFVIHLG
SPDNLSAYYQ ESGRAGRDGK RSYCRIYLSD QTLEQSKFFK NLTLKRIKYG KGDDEQKKAK
EDSLHYSFKK MNEYCEKNEC RHKMLCEYFG EDRKLPCDSN CDVCLNSKND KGNKGEKRGF
KRPASEMSIL KYTAEVTKRF HHSSDLMTSK NVKNFMQPQS RSLKSSSFTS GKNLFNQINY
RQP
//
