ID   A0A0K0EF02_STRER        Unreviewed;       831 AA.
AC   A0A0K0EF02;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=ELMO domain-containing protein {ECO:0000313|WBParaSite:SSTP_0000806600.1};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000806600.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000806600.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC       phagocytosis of apoptotic cells and cell motility. Acts in association
CC       with DOCK1 and CRK. Was initially proposed to be required in complex
CC       with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC       nucleotide exchange factor (GEF) activity of DOCK1.
CC       {ECO:0000256|ARBA:ARBA00024863}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A0K0EF02; -.
DR   STRING; 6248.A0A0K0EF02; -.
DR   WBParaSite; SSTP_0000806600.1; SSTP_0000806600.1; SSTP_0000806600.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR024574; ELMO_ARM.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12771:SF56; CED-12; 1.
DR   PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR   Pfam; PF11841; ELMO_ARM; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   Pfam; PF16457; PH_12; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681}.
FT   DOMAIN          378..575
FT                   /note="ELMO"
FT                   /evidence="ECO:0000259|PROSITE:PS51335"
SQ   SEQUENCE   831 AA;  95115 MW;  C88A0B1E45A33113 CRC64;
     MIQQSDGIIG KGLNPIDIRL PQSVFKGAVK LDPSISNYLI KPFKYPTDPR YLSCYVQYDK
     STDTLVEFLK NIIRQLELPP EDDIDGYSLT FEESGIFVTE ERISMLKQGF ILLLTASPKN
     YVQYVEGVLK TGSEYGQDTL RTLQLMERLS KDKIFLHVFE ENQGIGRIIS YIEGGKFSQN
     GTSLSCLFNI FLTLMSTLEV EDEDKASSYW YGLSNKFISE VASHISGRTK LESNESLNAS
     LNVIDFILKK CQKNQLCQLQ REVPFESLIM HLEKSDKRIP VAILNLMTSL YGVADESLKI
     EMLQILKDNA FRSMICKLLK KQDTTKLDQE LIKPMKSLQV IMMSDLATKA LKKPSEIEIE
     IIRNMESLNP CTFDSSAYHS SPVKSLGATT VTTFGVEEDD ISTSSFSELC PSLMINWNEF
     TDLVNKTPPG LLVLEAILYF DEKYPQLLKD INSENIVWQE TSSWPFPIVS IYLVSILIDL
     FSIVPSTSET GGSGGGGGPK IADKLKRVST FSKESGEVNK DDKLHLIFFT IESPFHELFS
     LSIRLFRRTW REMHASSEDL MKVIKVVREQ FERSLEFNPL TIKDYDNCLQ KFSYYQMQKI
     WESERFEKDQ SELQSDAIRH LTPKIRLKME KLVKQNRKNE MKKGCVFFKV PKDKSNIKIT
     SLGYWLWKLD RNERFLWYQD VDNESCLDMD MSKAKKLPIM EISSCIFEEA YAEYMLSTYG
     RKGTFKIPSR GIGICVNGSK DPDFNIASSN QKIVNIWIDG LNSLINDKLI TAESIVEVKK
     LADFDVKVRL MYIDCLPEIK ECEIGSKLER VIPPPPTDFS WIPLDSTNKL L
//