ID   A0A0K0EFK2_STRER        Unreviewed;      1795 AA.
AC   A0A0K0EFK2;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000313|WBParaSite:SSTP_0000826500.1};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000826500.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000826500.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
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DR   AlphaFoldDB; A0A0K0EFK2; -.
DR   STRING; 6248.A0A0K0EFK2; -.
DR   WBParaSite; SSTP_0000826500.1; SSTP_0000826500.1; SSTP_0000826500.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000557; Calponin_repeat.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR032629; DCB_dom.
DR   InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR   InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR   InterPro; IPR046455; Sec7/BIG1-like_C.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   InterPro; IPR003096; SM22_calponin.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF375; LD29171P; 1.
DR   Pfam; PF20252; BIG2_C; 1.
DR   Pfam; PF00402; Calponin; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF16213; DCB; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   Pfam; PF09324; Sec7-like_HDS; 1.
DR   Pfam; PF12783; Sec7-like_HUS; 1.
DR   PRINTS; PR00888; SM22CALPONIN.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS51122; CALPONIN_2; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          23..131
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          693..882
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
SQ   SEQUENCE   1795 AA;  204580 MW;  985D92F4193DE95A CRC64;
     MSRAEKSGIA FEAHQKVQSK FDPELAGQIL TWIRSISKQD FDTSGNMENF GSVLKNGVVL
     CNFANSLKSG AIKKINNSAM AFKQMENISF FLSFAEEYVN KSELFQTVDL YEAQDLNSVL
     ICLGALARKS EKHFGIPGLG PKEAEGEKRE WTEEQLKAGE GIIGLQAGSN KGANASGINM
     GNTRHMYVEM FLKTSIERIY NDKDIKKKDH INLKKACETA LEALKSYGES DNNTCNGSIL
     PTERGFVLAD NFFLPFELAC QAKSPRIVIT SLDCLQKLIA YGHLQGNIVD YENNDRMLID
     RIVEAICYPF QGPHTDDSVQ LQIIKAILAV VLSPSCHVHN GSLLLAIKTC FNIYLASKSN
     INQATARGIL TQIINTVFEA LQKKLKEKHL YKVDESDENV IKDVLESIVN KISNEIDTNI
     KKPTSSNSSI IEDNSECSDS ISNEFLNEQV SFSCPEEKDA FLLFRALCRL SMKVLPDNPD
     FKSHELRSKL LSLEMLLLII QNFHVNLPDK HCLVFAIRHY LCVALSKNSV SPFINVFEKS
     LAIFVLLVNK FKSHLKLQIE VFFREIILNI LESGSSSFEH KWIVLNTVAK ICEVPQSIVD
     IYVNYDCHLT SYNIFENLIS ILGKIAMGST IIDPTNLTVV QIKEKEKCMK VLGLNSLVEI
     LQCLTEWYSE VGSYTKVTDN DQDSDSETNS ISQFTQLKQQ KSIIEHGIDL FAKKAKHGLQ
     YLQEKKIVGT EPAEIAKFFF GEDRLDKTVV GDYLGDGDSF NKEVMYSYID LFDFTNMNIV
     AALRLLLEKF RLPGEAQKID RLMEKFASRF CECNSNLRLF ASADTAYVLS YSIIMLTTDL
     HSPQVKNKMT KEQYIAMNRG INDSADLPQE YLSEIYDEIA SNEIKMKPTL SGKKNTNNNL
     VQQTARQRKL IQNMELQSIS ENAFALMEQA ARSHIEFTNA SHIEHVKPMF EITWTPCLAA
     FSIGLQASDD VDIWTTCLDG FKLGIRISCL FQMTLERNAY VQALARFTLL TAKNSIREMK
     PKNVESIKLL MLVGEEDGDY LEECWYDVLK CISQLELAQN LVISNGKNNI VSNGQSAQLL
     LKNNGHVDEK LIHSLQECLG EASSQNVIVA VDKIFQNSSR LNGDAIVHFV TQLCKVSLEE
     LTVPGKPRLY MLQKIVEISF YNMDRIRIEW SRIWSILGEH FNVAGCSSRE NVSHFALDAL
     KQLSMKFLER GELPNFRFQK EFMKPFEIIM QKNSTLECRE MILACIANMV HSYSNRIKSG
     WKNIFSLFMV AGRDNRAPIV ECAFQTVTHI ITEVCKTNFI SIVDFFQDAV KCLSEFSCNY
     NYPDISMESI KLIRYCADHV SKNTYIFVEH CFDDISSNTS TPSMEVSSPL KIRQNSMQKV
     WLRGWFPIFS ELYYIINDCK LDVRTRSLTV MFDIIKTYGS EFEEEWWKDL FNVLFKIFDF
     SKLRDNPNHK NEWMTTTCNH ALYAVVDVFT KFYPSLIPTQ MLAFYELLYF FTEQLENDNL
     SRSAINCLEI LILSCGEKFS KDMWDHTIDL YERIFDVTMP HCTTNLLNSI SPTHIKKDIN
     NEESNKKGSE LTSKDKSDDY ELNILLNQYI AQLELVNSIN SLLFKKVTGV MSSENIDEYG
     STDVFGLLST DQLLKIVSSL IKSHKVSREF STNSVSRTVL WKALFKGKKK LNVVESETKT
     VNCVLSILFK LIESGFNDKE QIIIENIYKT LKETCIDCIT YYLLLDSASH KTTWQPIICL
     ILNHSIEQTK NNTIEGKEFS KFLAPYICKL IENEEPKCIR SLVSSFFEEA LKNYL
//