ID   A0A0K0EFM1_STRER        Unreviewed;      1736 AA.
AC   A0A0K0EFM1;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE            EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000828200.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000828200.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|RuleBase:RU363044};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU363044};
CC   -!- SIMILARITY: Belongs to the helicase family.
CC       {ECO:0000256|RuleBase:RU363044}.
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DR   AlphaFoldDB; A0A0K0EFM1; -.
DR   STRING; 6248.A0A0K0EFM1; -.
DR   WBParaSite; SSTP_0000828200.1; SSTP_0000828200.1; SSTP_0000828200.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR   CDD; cd22744; OTU; 1.
DR   CDD; cd18809; SF1_C_RecD; 1.
DR   Gene3D; 3.90.70.80; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR010285; DNA_helicase_pif1-like.
DR   InterPro; IPR025476; Helitron_helicase-like.
DR   InterPro; IPR003323; OTU_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR049163; Pif1-like_2B_dom.
DR   PANTHER; PTHR23274:SF49; ATP-DEPENDENT DNA HELICASE; 1.
DR   PANTHER; PTHR23274; DNA HELICASE-RELATED; 1.
DR   Pfam; PF14214; Helitron_like_N; 1.
DR   Pfam; PF05970; PIF1; 1.
DR   Pfam; PF21530; Pif1_2B_dom; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS50802; OTU; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU363044};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA damage {ECO:0000256|RuleBase:RU363044};
KW   DNA recombination {ECO:0000256|RuleBase:RU363044};
KW   DNA repair {ECO:0000256|RuleBase:RU363044};
KW   Helicase {ECO:0000256|RuleBase:RU363044};
KW   Hydrolase {ECO:0000256|RuleBase:RU363044};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681}.
FT   DOMAIN          82..232
FT                   /note="OTU"
FT                   /evidence="ECO:0000259|PROSITE:PS50802"
FT   COILED          1235..1274
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1736 AA;  204774 MW;  2879E5DA26D3204D CRC64;
     MLYIKKNFKR KRHNNISNIT SSSDSSSNIQ KKKFMKDIYK NDGIITHDIS NYFYQNNFNK
     NFYLKNIKYP LNIDINCYTY EYHLCKIKGD GNCAFRCMSI LIKDDCTKVE GFIRARQYII
     DFYNKIDNDD FFKEINKWIL PYLVIDNIQS NIKRLSWFES PAPPLYWGNE TDFSIFGLIF
     KLRILIFCDN KGKKSYYLCW KPYAFLYQNV INSWPLIIIY YNGFHYEIIT NLYYVSQPSL
     SSDDENDQLY QPSKYHISKI KKKRNIYYYS NDIVPYRLKK NYDNIHNLIN IYLPSSIKTI
     GFKKDIILEP RYFGNINDGG YCSFCKALYF YNENVGRRCC NNGKYNDEIK ITKNYPKELK
     DYFNPNHQIG KVFLSNIKKI NNDISFGQFN FTPCAIGKKN QPIIIKGNVI SRLNLKKFNI
     KKNNNKDFSK YLSKYLMYDA EECEAKTFSK KILFSKNIPH QNEIDFIKNH FSNYLARQDI
     SKIYTKINDI IPDSEKKYYQ LRVVKEDKPD KKNIEEKLDK NIIYYIYDSP DRSIPKMKVL
     IGTKSNISKK NKSSKHLILL SRNFQLIDTL TYSVLFPNGE VVYNMEKKKF DKKSYPTRRE
     FLRYNLYDRN DDTVFLKSCK LLQQYIIDYY IRIENDLMHY FKYHYKKMIK EKIKNYFINS
     DDIIDKEDSN SNEESDSIND NVTNQQIINS FTGGLSWYKF KYHNSLCVQK YYGLPDLLIT
     FTCNPYWPEI VESIGSGFKP MDRLDIICRV FYLKFKELLT LLKNGLFGPN IYLFYCIEIE
     KNGLPHGHII IKLKNFKKEP NFIDKIITAE IPGEKKDKQL YNLVIEHMLH NRCDELKEKA
     SCWDSCRNTC SKGYPKPFMN ETIIDADTEE IFYKRNSNNK MNKYVVPYNV FLLKYFNSSI
     NIRVVDNILG SSYIFKEMIA NKNSASKRIN LEILLNNKKK DEISNYQKVR CINTTDALWR
     IYQYPLLGHT IDVEILYIHE NILKNFTLPN YTIEAEDDIV KYILKTSKIG KSKLIAYFDL
     MKEEKEKKYP NKEILNLTYE EVPKFFKWDP LHPRDQVEVP RYKRGGWVKR TRKQNKIGRI
     IVVPKKFKEL YAMRCLLINR KGISSFDDLK TINGICYDTY EEAAYQFNLI NNTIIDKSYF
     LELKTIIEPE EFINLFIIYI KFDNNFNDHN SILQENKEYM SQPYKKMYSG QNDKDILNKA
     YNHLLHDILE KLMINGYDTE KSNLPLHKIN YNILLNIDEI NIKDEEKKLK LLKRQSNNKQ
     LEALNELKNL LKSNNNMKLM IIEGPAGTGK TFTYNLLGTY LKKKGKKFIN LGSTGISATL
     LENGQTVHSF FKMPLNINNT SFQITNDIVT KMTNNNIEKL EKCDVIFIDE VSILSQKQLE
     YIDLSLRKNL NKSKLFFGGK ILIIGGDFRQ CITIINDNPS SQEIISYTIL KSPYLKNESI
     KKIKLIENMR VENTEKEFSK FLLHIGNGVK KNKKNDNENY LYDGRMNNNR FVVIPQSMIF
     NGNDDAFIEE IFGKEKFLTN YNIAILAITN QYVTLLNEKI LFKYFDNIET FYSTDKLYYQ
     DVVKEDSDLF KNFTPSGYPK HKLNVSKGCI LICLKNLNIK EGLCNGTKII YKDIISINKG
     KRKLLKCTSL DGKKVYLIPQ IDNNPTDLNI PIPFTRYQFP VKLGFAFTIN KSQGQTFEKI
     GLYISQSVSF THGQLYVALS RVRNPNHIKI KWSYEQKADE IGKVKNIVER GILDLL
//