ID   A0A0K0EFR1_STRER        Unreviewed;       403 AA.
AC   A0A0K0EFR1;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Hydroxysteroid dehydrogenase-like protein 2 {ECO:0000256|ARBA:ARBA00040243};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000832100.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000832100.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC       {ECO:0000256|ARBA:ARBA00037788}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484}.
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DR   AlphaFoldDB; A0A0K0EFR1; -.
DR   STRING; 6248.A0A0K0EFR1; -.
DR   WBParaSite; SSTP_0000832100.1; SSTP_0000832100.1; SSTP_0000832100.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd09762; HSDL2_SDR_c; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003033; SCP2_sterol-bd_dom.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR42808; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR   PANTHER; PTHR42808:SF3; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF02036; SCP2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF55718; SCP-like; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681}.
FT   DOMAIN          309..397
FT                   /note="SCP2"
FT                   /evidence="ECO:0000259|Pfam:PF02036"
SQ   SEQUENCE   403 AA;  44785 MW;  F6745752ADBE6BF1 CRC64;
     MINVGKFAKK TVIITGASRG IGREIALKLA KDGANIVIAA KTATPHPKLA GTIYTVAEEI
     KKLGGKAMPC IVDVRDEKSI ENCVKETIKK FNGIDILVNN ASAINLTGTL ETSIKKYDLM
     HQVNVRGTYL MSQKCIPYLK QSSNPHILNI SPPLIMDKKW FQNHVAYTMT KYGMSMCVLG
     MHEEFRDHNI AVNALWPKTA IWTAAMEMLS SGEGEEGSRK PTIVADAAYA ILSKKSSDFT
     GNFTIDETIL RNEGVKNFDE YDCKPGAPLI PDFFISEEDL KTFTKVTSAK THIKDFPSAI
     KYFNQLLTPS LCEKINNVFQ LVIKKEDKTK FYILLDLVNK VAEEKKVDDA PCTIIFTESL
     FFDIVNGKTS LQDAIFSGKM NVKGNLILAN KLKSIFKSSM SKL
//