ID   A0A0K0EIG4_STRER        Unreviewed;       518 AA.
AC   A0A0K0EIG4;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=CNNM transmembrane domain-containing protein {ECO:0000313|WBParaSite:SSTP_0000926900.1};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000926900.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000926900.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ACDP family.
CC       {ECO:0000256|ARBA:ARBA00010484}.
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DR   AlphaFoldDB; A0A0K0EIG4; -.
DR   STRING; 6248.A0A0K0EIG4; -.
DR   WBParaSite; SSTP_0000926900.1; SSTP_0000926900.1; SSTP_0000926900.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008340; P:determination of adult lifespan; IEA:UniProt.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   GO; GO:1905941; P:positive regulation of gonad development; IEA:UniProt.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   TRANSMEM        156..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          152..333
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
SQ   SEQUENCE   518 AA;  58455 MW;  0E355F86DEB89B0E CRC64;
     MNTTPIIENS TEIKNQTSCN FNSNKNNSEI LISGLRLEGK DNSENFINKY TNDGIPIIEP
     KTEFKVVIFG YNLQHVDGIG FTVTGDCNDM IINVSSTNFM NITNKKIIFI AIFSDKGSIY
     NLCYLLKSNV KKYVFTKEKD INISTKVEPK KYIMPLWIQI CVIVFCAILS GLFSGLNLGL
     MTLTLQELEL ITKSGSEQDQ KYATVIIPIR KNGNFLLCSL IIGNVLVNSA ISILMDDLTS
     GLISLISSSA GIVLFGEIIP QSLCVKKGLA VGAKTIWITK FFMLITFPIS YPLSKLLDLV
     IGKEVTSYDR KKLMELIKMT TKNESAMEFK IAVGAMEITE KTVKDVMTKI EDVFMLPETT
     VLNEQKVTEI VNMGYTRIPV YANNNRNNVV SLLFIKDLAL MDPDQNFTVK TVCSYHQHFL
     KFVVEDTPLK AMLEEFKKGQ THLAMVRKKK STNKFKNVEE LCGLITLEDI LEEILKAEIV
     DETDIVIDNV NKVKRRTRNN KYLTNQIQFA GKKKSSFK
//