ID   A0A0K0EIH1_STRER        Unreviewed;       518 AA.
AC   A0A0K0EIH1;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE            EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000927600.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000927600.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC         EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A0K0EIH1; -.
DR   STRING; 6248.A0A0K0EIH1; -.
DR   WBParaSite; SSTP_0000927600.1; SSTP_0000927600.1; SSTP_0000927600.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR   Gene3D; 2.60.200.40; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR   PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   PROSITE; PS50146; DAGK; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681}.
FT   DOMAIN          119..266
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
SQ   SEQUENCE   518 AA;  59707 MW;  6CE8954E46CD641E CRC64;
     MTLKFRLKSF LRNDIFSKNV VGEISNDKII FTWSENDIEI NETYNVQDFI GAKEDIKNAD
     VVDAYFYLIN EKTSCRERLF IKMQAESLDQ KIELIKMFKS LIKIKQSPHM PKNTLVVSKN
     KYTVFVIINP FGGTQMARNQ WETEVKTIFD EADIIYTVYE TKCKLDATRV VNKLKIDKFD
     CIVVMGGDGM LSEVLNGILT RPDKERALKM PICHIPSGTC NAVASSICFQ ANEPFPPRDV
     FVKQAALMCV NPSYIPLRLS VVETKENGNI PMFLSATWGI IADIDIGSER FRWAGMLRLH
     IESYLRIFQL PSVANYEAII SYIPVEGYDR KKFKIRHVPS ERHLLGDDHF DYEEVKEWKF
     IESNNEEKNK ECLDDFFKKD NKLNIPSIDE TIPIDNKWVT YSEKVTTVSV IKLSHLGSDI
     PFLPCAKIDE DILYLCICKW EGMKNRFEMG FFLDDICRSN HLKYPFFDII PVKAARVEPI
     FRGNLGHFAV DGEPLKPGQI FQVRTLSKTA TLVTKKKV
//