ID   A0A0K0EME8_STRER        Unreviewed;       135 AA.
AC   A0A0K0EME8;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Gamma-secretase subunit PEN-2 {ECO:0000256|ARBA:ARBA00018306};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0001063600.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0001063600.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the PEN-2 family.
CC       {ECO:0000256|ARBA:ARBA00009607}.
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DR   AlphaFoldDB; A0A0K0EME8; -.
DR   STRING; 6248.A0A0K0EME8; -.
DR   WBParaSite; SSTP_0001063600.1; SSTP_0001063600.1; SSTP_0001063600.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR019379; Gamma_Secretase_Asp_P_PEN2.
DR   PANTHER; PTHR16318; GAMMA-SECRETASE SUBUNIT PEN-2; 1.
DR   PANTHER; PTHR16318:SF0; GAMMA-SECRETASE SUBUNIT PEN-2; 1.
DR   Pfam; PF10251; PEN-2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        53..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   135 AA;  15967 MW;  9D618639DF251862 CRC64;
     MTNTRNNSGN ENVRSRGHTS GENTIERVVH AANIHPEHSH KSMDKKLDEC KKYFKFGFFL
     LPSIWLIVVI TLFREYKNRN SAYAKKEEVR KYFERSLIGI IIYMIGFFIW LSFYITAYRN
     DAEWAYKIGA VYAIK
//