GenomeNet

Database: UniProt
Entry: A0A0K0ENL6_STRER
LinkDB: A0A0K0ENL6_STRER
Original site: A0A0K0ENL6_STRER 
ID   A0A0K0ENL6_STRER        Unreviewed;      1101 AA.
AC   A0A0K0ENL6;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|Proteomes:UP000035681, ECO:0000313|WBParaSite:SSTP_0001105300.1};
RN   [1] {ECO:0000313|Proteomes:UP000035681}
RP   NUCLEOTIDE SEQUENCE.
RA   Martin A.A.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SSTP_0001105300.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001436,
CC         ECO:0000256|RuleBase:RU003431};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A0K0ENL6; -.
DR   STRING; 6248.A0A0K0ENL6; -.
DR   WBParaSite; SSTP_0001105300.1; SSTP_0001105300.1; SSTP_0001105300.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06352; PBP1_NPR_GC-like; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   PANTHER; PTHR11920:SF495; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-7; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1101
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005328370"
FT   TRANSMEM        480..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          550..807
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          879..1009
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1075..1101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1101 AA;  126695 MW;  5BDD91A6D746A238 CRC64;
     MKVSNLFFLI ILSPLIKSQK NINLGFIFVK TDSEDGGVLG FTLAVGIVPV AIKRIMDEQL
     LPEYNFTFKY YFDNCIEANS SGSTHKLIVH DKVDVIFGPS CSRSAIRSAN VAQFYQKPLF
     IWGQVGTTQF ANINRFPNVY SATPVFYSLA LTVLDILKTF NWEKFVFLIV SRNSQRCSLM
     FDDFVNVSNA YEGFKPAMVS SFKPSTPPLD IEYDAFINET IKRARIILTC FDSRIWKRNF
     LLKMFDRGLN SPEYVHINME YAGRAFDSSR LDSNDKPIPF YIDSNEINDG RDNDAFEMAK
     RMFILDTVRY NYDNLSFDRE IIKNVKDWPF YCNECNITNK SSLNKYSKYL GDSIYMWGIL
     LNKSLNKYSN DVFNDPTLLR KDCMMNRESF TGKMHFDQNC IRLPLIQFTG LDSFGNQIPW
     FSYSFSSINN FERKNTVSSD QFDKTIFENW NNSIPLTEPV CGYLHNHCPI NFFKVYLKEV
     IIVGVIMIIL LILIIIGIIW YICKIRAQKE EELLKWKIPL SKLIKTSEKK DDTGSIHSSI
     SKMTSNTNKY SIHEKIDTEN YSFYLYYDES VVGRKYKVIF NLIKNDYIEL NEMLSIDHQN
     INKFFGMCAD ECLPMSIWRY CKRGSLHEIL QTEIPNFDSY FMMSLIKDIC NGLLYIHSSF
     INFHGTLTSK ICLVSDRWQV KISNFSPKNL SRYEDISKEN LLWRAPEHLN DDFSIGSKEG
     DIYSFAIILS EVISKGNFWN LNQREEGIDE LIYLVKRGDS PPIRPEIVVA PNIEVNPSLI
     TLTKDCWNDS SKNRPTIKQV ESVLKAFNKD GPKNLMDHVF KTLEEYASTL QDEVNERTKE
     VVEEQKKSDL LLKKMLPGEI VNKLKLGKVI EPENFDQVTV FFADIVKFTI LASKCSPFQV
     VTLVNDLFVL FDNLIETLDI YKVETIGDGY LCVSGLPTRN GNMHAKEIAE LAIGFNKICR
     NFFIPYLPNE KIMVRVGCNS GPCVAGVVGL SMPRYCLFGD TVNTASRMES NGKPGKIHIT
     ENCSKLLNTI GGYIIEPRGE VIIKGKGVMN TFWLIGRVGE SNNNLINDND NEVRHEKNLS
     NDKKNTETKE GMYREFNQND N
//
DBGET integrated database retrieval system